Evidence map›Paper›PMID 30973324›Full record

ArticleeLife2019

Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells.

Hirofumi Noguchi, Jesse Garcia Castillo, Kinichi Nakashima, Samuel J Pleasure

Abstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. SETDB1 ensures the continuity of embryonic to adult neural stem cells through metabolic alterations in the dentate gyrus.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Adult neurogenesis: a real hope or a delusion?Neural regeneration research · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Recent advances in tissue stem cells.Science China. Life sciences · 2021
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hirofumi NoguchiDepartment of Neurology, University of California, San Francisco, San Francisco, United States.ORCID 0000-0002-9779-4956
Jesse Garcia CastilloDepartment of Neurology, University of California, San Francisco, San Francisco, United States.
Kinichi NakashimaDepartment of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Samuel J PleasurePrograms in Neuroscience and Developmental Biology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, United States.ORCID 0000-0001-8599-1613

Funding

SDF1/CXCR4 Signaling and Tangential Neuronal Migration in the Developing CortexR01MH077694 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PLEASURE, SAMUEL JEREMY · 2007 to 2019
$5.0M
Exploiting the hair-brain connection to treat perinatal brain diseaseR01NS075188 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PLEASURE, SAMUEL JEREMY · 2011 to 2014
$1.4M
Japan Science Society Sasakawa Scientific Research GrantJapan Society for the Promotion of Science Overseas Research FellowshipNIH HHS R01 NS075188NIMH NIH HHS R01 MH077694NINDS NIH HHS R01 NS075188
6 · The paper itself

Abstract

Adult hippocampal neurogenesis requires the quiescent neural stem cell (NSC) pool to persist lifelong. However, establishment and maintenance of quiescent NSC pools during development is not understood. Here, we show that Suppressor of Fused (Sufu) controls establishment of the quiescent NSC pool during mouse dentate gyrus (DG) development by regulating Sonic Hedgehog (Shh) signaling activity. Deletion of

Indexed as

Gene Expression Regulation, DevelopmentalNeurogenesisAnimalsCell ProliferationDentate GyrusGene Knockout TechniquesHedgehog ProteinsMiceNeural Stem CellsRepressor ProteinsSignal TransductionHedgehog ProteinsRepressor ProteinsShh protein, mouseSufu protein, mousedentate gyrusdevelopmental biologyhippocampal developmentmouseneurosciencesonic hedgehogstem cell

Identifiers

PMID30973324
PMCPMC6459675

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.