Evidence map›Paper›PMID 30972968›Full record

ArticleMolecular genetics & genomic medicine2019

Association of OPG gene polymorphisms with the risk of knee osteoarthritis among Chinese people.

Yuxin Qi, Feimeng An, Jiaqi Wang, Yuan Liu, Hongyan Gao, Zhe Ge, Enze Jiang, Donggao Cai, Jianping Shi, Jianzhong Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics & genomic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Yuxin QiInner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Feimeng AnInner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Jiaqi WangInner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Yuan LiuInner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Hongyan GaoThe 2nd affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Zhe GeDepartment of Orthopaedics, Jinshan Hospital, Fudan University, Shanghai City, China.
Enze JiangShanghai Changzheng hospital, Shanghai, China.
Donggao CaiShengjing Hospital affiliated to China Medical University, Shenyang, China.
Jianping ShiInner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Jianzhong WangThe 2nd affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.ORCID 0000-0003-4031-1316
Second Affiliated Hospital of Inner Mongolia Medical University · CNInner Mongolia Medical University · CNShanghai Changzheng Hospital · CNJinshan Hospital of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOsteoarthritis (OA) is usually recognized to have a genetic factor, and in our study, we performed a case-control study to analyze the association between 14 single nucleotide polymorphisms (SNPs) in OPG and the risk of knee OA in a Chinese Han population.

methodsFourteen OPG SNPs were assayed using MassARRAY in 393 patients clinically and radiographically diagnosed with knee OA and in 500 controls. Allelic and genotypic frequencies were compared between the groups. Logistic regression adjusting for age and gender was used to estimate risk associations between specific genotypes and knee OA by computing odds ratios (ORs) and 95% confidence intervals (95% CIs).

resultsWe found that the minor alleles of six SNPs in OPG were associated with an increased or decreased risk of knee OA in the allelic model analysis. In the genetic model analysis, we found that rs1905786, rs1032128, rs3134058, rs11573828, rs11573849, rs3134056, and rs1564861 were associated with an increased or decreased risk of knee OA before adjusted by sex and age. And after adjustment, three SNPs (rs1485286, rs1905786, and rs1032128) were identified to have a negative effect on knee OA.

conclusionOur results verify that genetic variants of OPG contribute to knee OA susceptibility in the population of northern China. These genetic associations may identify individuals at a particularly high risk of developing knee OA.

Indexed as

AgedAllelesAsian PeopleCase-Control StudiesChinaFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHaplotypesHumansMaleMiddle AgedOdds RatioOsteoarthritis, KneeOsteoprotegerinTNFRSF11B protein, humanChinese peoplegene polymorphismsknee osteoarthritisOPG

Identifiers

PMID30972968
PMCPMC6565555
OpenAlexW2938764853

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