Evidence map›Paper›PMID 30972950›Full record

ArticleCancer medicine2019

Vitamin D

Brittany L Bunch, Yingyu Ma, Kristopher Attwood, Lauren Amable, Wei Luo, Carl Morrison, Khurshid A Guru, Anna Woloszynska-Read, Pamela A Hershberger, Donald L Trump and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Modulating effect of vitamin D3 on the mutagenicity and carcinogenicity of doxorubicin in Drosophila melanogaster and in silico studies.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2020
    Article
  7. Article
  8. Forkhead Box R2 Knockdown Decreases Chemoresistance to Cisplatin via MYC Pathway in Bladder Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Article
  9. Vitamin DCancer medicine · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Brittany L BunchDepartment of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York.ORCID 0000-0001-7302-8360
Yingyu MaDepartment of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York.ORCID 0000-0003-1800-6219
Kristopher AttwoodDepartment of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, New York.
Lauren AmableNational Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, Maryland.
Wei LuoDepartment of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York.ORCID 0000-0003-2932-1353
Carl MorrisonDepartment of Pathology, Roswell Park Cancer Institute, Buffalo, New York.
Khurshid A GuruDepartment of Urology, Roswell Park Cancer Institute, Buffalo, New York.
Anna Woloszynska-ReadDepartment of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York.ORCID 0000-0001-5279-9414
Pamela A HershbergerDepartment of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York.
Donald L TrumpInova Schar Cancer Institute, Falls Church, Virginia.
Candace S JohnsonDepartment of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York.
Roswell Park Comprehensive Cancer Center · USNational Institutes of Health · USVirginia Cancer Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin D

methodsTo test effects of VitD supplementation on the response to cisplatin we analyzed patient serum VitD levels and correlated that with survival. In vivo, VitD deficient mice were treated with cisplatin, with or without pretreatment with the active VitD metabolite, 1,25 dihydroxyvitamin D

resultsIn this study, we determined that low serum 25 hydroxyvitamin D

conclusionsOur data suggest that VitD deficiency could be a biomarker for poor response to cisplatin, and pretreating with VitD can increase the apoptotic response to cisplatin through VDR and TAp73 signaling crosstalk.

Indexed as

AnimalsApoptosisCell Line, TumorCholecalciferolCisplatinDisease Models, AnimalDrug SynergismFemaleGene ExpressionHumansImmunohistochemistryMiceModels, BiologicalPrognosisReceptors, CalcitriolSignal TransductionCholecalciferolCisplatinReceptors, CalcitriolTumor Protein p73VDR protein, humanbladder cancercisplatinTAp73VDRvitamin D3

Identifiers

PMID30972950
PMCPMC6537042
OpenAlexW2938438980

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.