ArticleCell proliferation2019
Fabrication of Chitosan/Polypyrrole-coated poly(L-lactic acid)/Polycaprolactone aligned fibre films for enhancement of neural cell compatibility and neurite growth.
Article in Cell proliferation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Electrospinning PLLA/PCL Blend Fibre-Based Materials and Their Biomedical Application: A Mini Review.Polymers · 2025Review
- Advances in Polypyrrole Nanofiber Composites: Design, Synthesis, and Performance in Tissue Engineering.Materials (Basel, Switzerland) · 2025Review
- Biomaterials for neuroengineering: applications and challenges.Regenerative biomaterials · 2025Review
- The Alphabet of Nanostructured Polypyrrole.Materials (Basel, Switzerland) · 2023Review
- Effects of ceramic additives and bioactive coatings on the degradation of polylactic acid-based bone scaffolds under hydrolytic conditions.Journal of biomedical materials research. Part B, Applied biomaterials · 2023Article
- Electric field bridging-effect in electrified microfibrils' scaffolds.Frontiers in bioengineering and biotechnology · 2023Article
- Electrical Stimulation Increases Axonal Growth from Dorsal Root Ganglia Co-Cultured with Schwann Cells in Highly Aligned PLA-PPy-Au Microfiber Substrates.International journal of molecular sciences · 2022Article
- Design and Fabrication of Nanofibrous Dura Mater with Antifibrosis and Neuroprotection Effects on SH-SY5Y Cells.Polymers · 2022Article
- Engineering Tissues of the Central Nervous System: Interfacing Conductive Biomaterials with Neural Stem/Progenitor Cells.Advanced healthcare materials · 2022Review
- Graphene oxide-composited chitosan scaffold contributes to functional recovery of injured spinal cord in rats.Neural regeneration research · 2021Article
- 3D Electrospun Synthetic Extracellular Matrix for Tissue Regeneration.Small science · 2021Article
- Conductive Electrospun Nanofiber Mats.Materials (Basel, Switzerland) · 2019Review
- Fabrication of Chitosan/Polypyrrole-coated poly(L-lactic acid)/Polycaprolactone aligned fibre films for enhancement of neural cell compatibility and neurite growth.Cell proliferation · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveChitosan (CS) and polycaprolactone (PCL) were added into a nerve scaffold of poly(L-lactide acid) (PLLA)/polypyrrole (PPy)-based fibre films to solve the unmatch with the nerve strength and the aseptic inflammation from PLLA.
methodsPoly (L-lactide acid)-polycaprolactone (PLLA/PCL) fibre films coated with chitosan (CS) and polypyrrole (PPy) were prepared by electrospinning of aligned PLLA/PCL fibres, electrochemical deposition of PPy nanoparticles and in situ doping of CS in PPy. PC12 cells were electrically stimulated with 100 mV for 2 hours every day via CS/PPy-PLLA/PCL fibre film to promote the neurite growth.
resultsThe surface conductivity and tensile strength of CS/PPy-PLLA/PCL fibre films were 1.03 s/m and 13 MPa, respectively. CS content in fibre films was about 7.5 mg/cm
conclusionsA synergistic mechanism about the promotion of CS, electrical stimulation and aligned fibres on PC12 cells differentiation, axon outgrowth was proposed. These results indicated the potential application of CS/PPy-PLLA/PCL fibre film in the field of the nerve repair and regeneration.
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Registered trials
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