ArticleJournal of fish diseases2019
Melanized focal changes in skeletal muscle in farmed Atlantic salmon after natural infection with Piscine orthoreovirus (PRV).
Article in Journal of fish diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- Melanized Focal Changes in the Fillets of Farmed Atlantic Salmon: A Clinical Report From a Deep-Sea Production Site.Journal of fish diseases · 2026Article
- Beating Cardiac Cell Cultures From Different Developmental Stages of Rainbow Trout as a Novel Approach for Replication of Cardiac Fish Viruses.Journal of fish diseases · 2025Article
- Melanisation in Salmonid Skeletal Muscle: A Review.Journal of fish diseases · 2025Review
- Factors Influencing the Prevalence of Hyperpigmented Melanistic Lesions in Smallmouth Bass Micropterus dolomieu in the Susquehanna River Basin, Pennsylvania.Journal of fish diseases · 2025Article
- Analysis of morphology, histology characteristics, and circadian clock gene expression of Onychostoma macrolepis at the overwintering period and the breeding period.Fish physiology and biochemistry · 2024Article
- Cellular heterogeneity in red and melanized focal muscle changes in farmed Atlantic salmon (Salmo salar) visualized by spatial transcriptomics.Cell and tissue research · 2024Article
- Eumelanin Detection in Melanized Focal Changes but Not in Red Focal Changes on Atlantic Salmon (International journal of molecular sciences · 2023Article
- In-depth health surveillance and clinical nutrition in farmed Atlantic salmon: a strategic attempt to detect and mitigate an HSMI outbreak.Veterinary research · 2023Article
- Anatomy of teleost fish immune structures and organs.Immunogenetics · 2021Review
- PRV-1 Infected Macrophages in Melanized Focal Changes in White Muscle of Atlantic Salmon (Frontiers in immunology · 2021Article
- Dynamics of Polarized Macrophages and Activated CD8Frontiers in immunology · 2021Article
- Transcriptome Responses of Atlantic Salmon (Frontiers in immunology · 2021Article
- Emergence and Spread ofPathogens (Basel, Switzerland) · 2020Article
- Erythroid Progenitor Cells in Atlantic Salmon (Viruses · 2019Article
- Melanized focal changes in skeletal muscle in farmed Atlantic salmon after natural infection with Piscine orthoreovirus (PRV).Journal of fish diseases · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Melanized focal changes in skeletal muscle of farmed Atlantic salmon (Salmo salar) are a major quality problem. The aetiology is unknown, but infection with Piscine orthoreovirus (PRV) has been associated with the condition. Here, we addressed the pathogenesis of red and melanized focal changes and their association with PRV. First, a population of farmed fish (PRV-negative prior to sea transfer) was sequentially investigated throughout the seawater period. The fish were autopsied and tested for PRV infection. Muscular changes were described by macroscopy and histology, and a classification system was established. Second, in an experimental infection trial, PRV was injected intramuscularly to induce changes. The farmed fish was gradually infected with PRV. Red focal changes occurred throughout the observation period with a low prevalence regardless of PRV status. Melanized changes were highly diverse and their prevalence increased during the trial. Changes of low macroscopic grade and histological category were more prevalent in PRV-negative fish. Diffuse granulomatous melanized changes only occurred after PRV infection. No muscular changes were observed in the experimentally challenged fish. Our studies do not indicate that PRV infection causes red focal changes, but seems important in the development of granulomatous melanized changes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.