Evidence map›Paper›PMID 30972697›Full record

ArticleJournal of physiology and biochemistry2019

α2,6-Sialylation promotes immune escape in hepatocarcinoma cells by regulating T cell functions and CD147/MMP signaling.

Liping Wang, Shijun Li, Xiao Yu, Yang Han, Yinshuang Wu, Shidan Wang, Xixi Chen, Jianing Zhang, Shujing Wang

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Journal of physiology and biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
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  11. Article
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  13. ST6Gal1: Oncogenic signaling pathways and targets.Frontiers in molecular biosciences · 2022
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Liping Wang *Department of Biochemistry and Molecular Biology, Institute of Glycobiology, Dalian Medical University, Dalian, 116044, China.
Shijun Li *Department of inspection, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, Liaoning Province, China.
Xiao YuDepartment of Pathology, Dalian Medical University, Dalian, 116044, Liaoning Province, China.
Yang HanDepartment of Biochemistry and Molecular Biology, Institute of Glycobiology, Dalian Medical University, Dalian, 116044, China.
Yinshuang WuDepartment of Biochemistry and Molecular Biology, Institute of Glycobiology, Dalian Medical University, Dalian, 116044, China.
Shidan WangDepartment of Biochemistry and Molecular Biology, Institute of Glycobiology, Dalian Medical University, Dalian, 116044, China.
Xixi ChenSchool of Life Science and Medicine, Dalian University of Technology, Panjin, 124221, Liaoning, China.
Jianing ZhangSchool of Life Science and Medicine, Dalian University of Technology, Panjin, 124221, Liaoning, China. jnzhang@dlut.edu.cn.
Shujing WangDepartment of Biochemistry and Molecular Biology, Institute of Glycobiology, Dalian Medical University, Dalian, 116044, China. wangshujing@dlmedu.edu.cn.

Funding

National Natural Science Foundation of China NO.31470799Natural Science Foundation of Liaoning Province (CN) NO.20170540288
6 · The paper itself

Abstract

Altered glycosylation is a common feature of cancer cells and plays an important role in tumor progression. β-Galactoside α2-6-sialyltransferase 1 (ST6Gal-I) is the critical sialyltransferase responsible for the addition of α2-6-sialic acid to the terminal N-glycans on the cell surface. However, the functions and mechanism of ST6Gal-I in tumor immune escape remain poorly understood. Here, we found that ST6Gal-I overexpression promoted hepatocarcinoma cell proliferation, migration, and immune escape by increasing the levels of CD147, MMP9, MMP2, and MMP7. When CD8

Indexed as

Tumor EscapeAnimalsAntigens, CDApoptosisBasiginbeta-D-Galactoside alpha 2-6-SialyltransferaseCarcinoma, HepatocellularCD8-Positive T-LymphocytesCell Line, TumorCell MovementCell ProliferationGlycosylationHumansInterferon-gammaInterleukin-10Liver NeoplasmsAntigens, CDBasiginbeta-D-Galactoside alpha 2-6-SialyltransferaseBSG protein, humanIL10 protein, humanInterferon-gammaInterleukin-10Matrix Metalloproteinase 2Matrix Metalloproteinase 7Matrix Metalloproteinase 9MMP2 protein, humanMMP7 protein, humanMMP9 protein, humanN-Acetylneuraminic AcidSialyltransferasesST6GAL1 protein, humanTransforming Growth Factor beta1Tumor Necrosis Factor-alphaCD147HCCImmune escapeST6Gal-IT cell

Identifiers

PMID30972697

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.