Evidence map›Paper›PMID 30972623›Full record

Trial reportSurgical endoscopy2020

Margin diagnosis for endoscopic submucosal dissection of early gastric cancer using multiphoton microscopy.

Xiaoling Zheng, Ning Zuo, Hongxin Lin, Liqin Zheng, Ming Ni, Guizhu Wu, Jianxin Chen, Shuangmu Zhuo

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Surgical endoscopy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Xiaoling ZhengDepartment of Endoscopy, Fujian Provincal Hospital, Fujian Medical University & College of Photonic and Electronic Engineering, Fujian Normal University, Fuzhou, China.
Ning ZuoFujian Provincial Key Laboratory for Photonics Technology & Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou, China.
Hongxin LinFujian Provincial Key Laboratory for Photonics Technology & Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou, China.
Liqin ZhengFujian Provincial Key Laboratory for Photonics Technology & Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou, China.
Ming NiSchool of Biological Sciences & Engineering, Yachay Tech University, Hacienda San José s/n, 100105, San Miguel de Urcuquí, Ecuador.
Guizhu WuShanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China. wugz6666@126.com.
Jianxin ChenFujian Provincial Key Laboratory for Photonics Technology & Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou, China.
Shuangmu ZhuoDepartment of Endoscopy, Fujian Provincal Hospital, Fujian Medical University & College of Photonic and Electronic Engineering, Fujian Normal University, Fuzhou, China. shuangmuzhuo@gmail.com.ORCID 0000-0001-5767-5197
Fujian Normal University · CNShanghai First Maternity and Infant Hospital · CNUniversidad Yachay Tech · EC

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsEndoscopic submucosal dissection (ESD) has become the primary option for the treatment of early gastric cancer (EGC). Thus, it is necessary to diagnose whether residual cancer cells exist in the ESD specimen margins, which can affect tumor recurrence and survival rates in the future. Multiphoton microscopy (MPM) can be suitably used for nondestructive imaging of biological tissue on a cellular level to enable real-time guidance during endoscopic therapy. Considering this, the objective of this study is to explore the practicality of MPM for the diagnosis of ESD specimen margins in the case of EGC.

methodsFirst, a total of 20 surgical samples was imaged using the proposed MPM technique to obtain two-photo excited fluorescence signal from the intrinsic fluorescent substances within cells and second-harmonic generation signal from collagen; these signals were used to determine MPM pathological features for margin diagnosis. Then, a double-blind study of 50 samples was conducted to evaluate the diagnosis results based on the obtained MPM pathological features.

resultsMultiphoton microscopy can accurately identify the cytological and morphological differences between tissue in the negative and positive margin. The sensitivity, specificity, accuracy, negative predictive, and positive predictive values of MPM in the diagnosis of ESD specimen margins were 97.62, 75.00, 94.00, 95.35, and 85.71%, respectively.

conclusionThese results indicate that MPM can be used as an effective, real-time, and label-free novel method to determine intraoperative resection margins.

Indexed as

Endoscopic Mucosal ResectionMargins of ExcisionMicroscopy, Fluorescence, MultiphotonAdenocarcinomaAgedAged, 80 and overDouble-Blind MethodFemaleGastrectomyHumansMaleMiddle AgedPilot ProjectsProspective StudiesSensitivity and SpecificityStomach NeoplasmsEarly gastric cancerESDMultiphoton microscopyResection margin

Identifiers

PMID30972623
OpenAlexW2938433860

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.