Evidence map›Paper›PMID 30972508›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2019

Dopamine-beta-hydroxylase 19-bp insertion/deletion polymorphism affects medication overuse in patients with chronic migraine.

Piero Barbanti, Fiorella Guadagni, Maria Laura De Marchis, Cristiano Ialongo, Gabriella Egeo, Luisa Fofi, Cinzia Aurilia, Domenica Lovero, David Della-Morte, Patrizia Ferroni and 1 more

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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Chronic migraine: Genetics or environment?European journal of neurology · 2021
    Article
  6. Machine learning approach to predict medication overuse in migraine patients.Computational and structural biotechnology journal · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Piero BarbantiHeadache and Pain Unit, Department of Neurological, Motor and Sensorial Sciences, IRCCS San Raffaele Pisana, Rome, Italy.
Fiorella GuadagniBiobanca InterIstituzionale Multidisciplinare, IRCCS San Raffaele Pisana, Rome, Italy.
Maria Laura De MarchisBiobanca InterIstituzionale Multidisciplinare, IRCCS San Raffaele Pisana, Rome, Italy.
Cristiano IalongoDepartment of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.
Gabriella EgeoHeadache and Pain Unit, Department of Neurological, Motor and Sensorial Sciences, IRCCS San Raffaele Pisana, Rome, Italy.
Luisa FofiHeadache and Pain Unit, Department of Neurological, Motor and Sensorial Sciences, IRCCS San Raffaele Pisana, Rome, Italy.
Cinzia AuriliaHeadache and Pain Unit, Department of Neurological, Motor and Sensorial Sciences, IRCCS San Raffaele Pisana, Rome, Italy.
Domenica LoveroDepartment of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", Bari, Italy.
David Della-MorteDepartment of Human Sciences and Quality of Life Promotion, San Raffaele Roma Open University, Rome, Italy.
Patrizia FerroniBiobanca InterIstituzionale Multidisciplinare, IRCCS San Raffaele Pisana, Rome, Italy.
Raffaele PalmirottaBiobanca InterIstituzionale Multidisciplinare, IRCCS San Raffaele Pisana, Rome, Italy. raffaelepalmirotta@gmail.com.ORCID http://orcid.org/0000-0002-9401-7377

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dopamine-beta-hydroxylase (DBH) enzyme activity is modulated at the genetic level by the presence of several polymorphisms. Among these, the 19-bp insertion/deletion (I/D) polymorphism (rs72393728/rs141116007) was investigated in several genetic association studies for its correlation with the susceptibility to develop episodic migraine, but conflicting results were achieved. In the present study we analyzed this genetic variant in a carefully characterized population of migraineurs encompassing both episodic and chronic migraine (with and without medication overuse) with the aim to perform a replication study and verify any possible correlation with migraine endophenotypes. Genotyping of the DBH 19-bp I/D polymorphism was performed on 400 migraine patients and 204 healthy individuals. The associations between genotypic frequencies and the clinical and sociodemographic features of migraineurs were then investigated. The DBH 19-bp I/D polymorphism did not correlate with migraine susceptibility or most clinical variables, with the exception of a statistically significant correlation within the subgroup of patients affected by chronic migraine were the individuals carrying the deleted (D) allele were significantly more prone to abuse in analgesics. As a result of this finding, the DBH 19-bp I/D polymorphism does not influence migraine susceptibility, but it might contribute to the development of medication overuse in patient with chronic migraine.

Indexed as

Prescription Drug OveruseAdultChronic DiseaseDopamine beta-HydroxylaseFemaleGenetic Predisposition to DiseaseGenotypeHumansINDEL MutationMaleMiddle AgedMigraine DisordersDopamine beta-Hydroxylase19-bp insertion/deletion polymorphismDopamine-beta-hydroxylaseGeneticMedication overuseMigraine

Identifiers

PMID30972508

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.