Evidence map›Paper›PMID 30972427›Full record

ArticleCancer immunology, immunotherapy : CII2019

Cryptotanshinone has curative dual anti-proliferative and immunotherapeutic effects on mouse Lewis lung carcinoma.

Shuo Liu, Zhen Han, Anna L Trivett, Hongsheng Lin, Sean Hannifin, De Yang, Joost J Oppenheim

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
6.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 45 citations in OpenAlex.

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  19. Experimental and therapeutic medicine · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Shuo LiuCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research (FNLCR), Rm 21-89/31-19, Bldg 560, 1050 Boyles Street, Frederick, MD, 21702-1201, USA.
Zhen HanCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research (FNLCR), Rm 21-89/31-19, Bldg 560, 1050 Boyles Street, Frederick, MD, 21702-1201, USA.
Anna L TrivettCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research (FNLCR), Rm 21-89/31-19, Bldg 560, 1050 Boyles Street, Frederick, MD, 21702-1201, USA.
Hongsheng LinGuang An Men Hospital of China Academy of Chinese Medical Sciences, Beijing, China.
Sean HannifinCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research (FNLCR), Rm 21-89/31-19, Bldg 560, 1050 Boyles Street, Frederick, MD, 21702-1201, USA.
De YangCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research (FNLCR), Rm 21-89/31-19, Bldg 560, 1050 Boyles Street, Frederick, MD, 21702-1201, USA. yangd@mail.nih.gov.
Joost J OppenheimCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research (FNLCR), Rm 21-89/31-19, Bldg 560, 1050 Boyles Street, Frederick, MD, 21702-1201, USA. oppenhej@mail.nih.gov.ORCID http://orcid.org/0000-0003-0271-7921
Frederick National Laboratory for Cancer Research · USChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer is currently the leading cause of cancer-related mortality with very limited effective therapy. Screening of a variety of traditional Chinese medicines (TCMs) for their capacity to inhibit the proliferation of human lung cancer A549 cells and to induce the in vitro maturation of human DCs led to the identification of cryptotanshinone (CT), a compound purified from the TCM Salvia miltiorrhiza Bunge. Here, CT was shown to inhibit the proliferation of mouse Lewis lung carcinoma (LLC) cells by upregulating p53, downregulating cyclin B1 and Cdc2, and, consequently, inducing G2/M cell-cycle arrest of LLC cells. In addition, CT promoted maturation of mouse and human DCs with upregulation of costimulatory and MHC molecules and stimulated DCs to produce TNFα, IL-1β, and IL-12p70, but not IL-10 in vitro. CT-induced maturation of DCs depended on MyD88 and also involved the activation of NF-κB, p38, and JNK. CT was effective in the treatment of LLC tumors and, when used in combination with low doses of anti-PD-L1, cured LLC-bearing mice with the induction of subsequent anti-LLC long-term specific immunity. CT treatment promoted T-cell infiltration and elevated the expression of genes typical of Th1 polarization in LLC tumor tissue. The therapeutic effect of CT and low doses of anti-PD-L1 was reduced by depletion of CD4 and CD8 T cells. This paper provides the first report that CT induces immunological antitumor activities and may provide a new promising antitumor immunotherapeutic.

Indexed as

A549 CellsAnimalsAntineoplastic Combined Chemotherapy ProtocolsB7-H1 AntigenCarcinoma, Lewis LungCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell ProliferationDendritic CellsFemaleHumansImmunotherapyMiceMice, Inbred C57BLPhenanthrenesTreatment OutcomeB7-H1 AntigenCD274 protein, humancryptotanshinonePhenanthrenesCancer therapeuticCell-cycle arrestCryptotanshinoneDendritic cellsLewis lung carcinoma

Identifiers

PMID30972427
PMCPMC6584267
OpenAlexW2937168653

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.