ArticleAesthetic surgery journal2020
Pro-Fibrotic CD26-Positive Fibroblasts Are Present in Greater Abundance in Breast Capsule Tissue of Irradiated Breasts.
Article in Aesthetic surgery journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Breast Capsule Thickness and Clinical Capsular Contracture: A Systematic Review and Meta-Analysis.Aesthetic plastic surgery · 2026Pooled it
- Advances in Etiology and Prevention of Capsular Contracture After Breast Implantation.Aesthetic plastic surgery · 2025Review
- Implant-based breast surgery and capsular formation: when, how and why?-a narrative review.Annals of translational medicine · 2023Review
- Adipose derived stem cell extracellular vesicles modulate primary human macrophages to an anti-inflammatory phenotype in vitro.Journal of extracellular biology · 2023Article
- Mesenchymal stromal cells in the thymus.Inflammation and regeneration · 2022Review
- A Novel Xenograft Model Demonstrates Human Fibroblast Behavior During Skin Wound Repair and Fibrosis.Advances in wound care · 2022Article
- TGF-β1 mediates pathologic changes of secondary lymphedema by promoting fibrosis and inflammation.Clinical and translational medicine · 2022Article
- Another Wrinkle with Age: Aged Collagen and Intra-peritoneal Metastasis of Ovarian Cancer.Aging and cancer · 2022Article
- CD26/DPP-4 in Chronic Myeloid Leukemia.Cancers · 2022Review
- The fibroblast: An emerging key player in thymic T cell selection.Immunological reviews · 2021Review
- Deciphering the temporal heterogeneity of cancer-associated fibroblast subpopulations in breast cancer.Journal of experimental & clinical cancer research : CR · 2021Article
- Fibroblasts direct differentiation of human breast epithelial progenitors.Breast cancer research : BCR · 2020Article
- Fat grafting rescues radiation-induced joint contracture.Stem cells (Dayton, Ohio) · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundBreast capsular contracture is a major problem following implant-based breast reconstruction, particularly in the setting of radiation therapy. Recent work has identified a fibrogenic fibroblast subpopulation characterized by CD26 surface marker expression.
objectivesThis work aimed to investigate the role of CD26-positive fibroblasts in the formation of breast implant capsules following radiation therapy.
methodsBreast capsule specimens were obtained from irradiated and nonirradiated breasts of 10 patients following bilateral mastectomy and unilateral irradiation at the time of expander-implant exchange, under institutional review board approval. Specimens were processed for hematoxylin and eosin staining as well as for immunohistochemistry and fluorescence activated cell sorting for CD26-positive fibroblasts. Expression of fibrotic genes and production of collagen were compared between CD26-positive, CD26-negative, and unsorted fibroblasts.
resultsCapsule specimens from irradiated breast tissue were thicker and had greater CD26-postive cells on immunofluorescence imaging and on fluorescence activated cell sorting analysis than did capsule specimens from the nonirradiated breast. Compared with CD26-negative fibroblasts, CD26-positive fibroblasts produced more collagen and had increased expression of the profibrotic genes IL8, TGF-β1, COL1A1, and TIMP4.
conclusionsCD26-positive fibroblasts were found in a significantly greater abundance in capsules of irradiated compared with nonirradiated breasts and demonstrated greater fibrotic potential. This fibrogenic fibroblast subpopulation may play an important role in the development of capsular contracture following irradiation, and its targeted depletion or moderation may represent a potential therapeutic option. LEVEL OF EVIDENCE: 2:
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.