ArticleThe Journal of infectious diseases2019
Early Measles Vaccination During an Outbreak in the Netherlands: Short-Term and Long-Term Decreases in Antibody Responses Among Children Vaccinated Before 12 Months of Age.
Article in The Journal of infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The trial behind it
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Immunogenicity and safety of a measles and rubella-containing vaccine at age 6 and 9 months in Bangladesh: an open-label, randomised trial.The Lancet. Child & adolescent health · 2025Trial
- Measles-mumps-rubella-vaccination at 6 months of age induces measles-specific T cell responses: a randomized controlled trial.Frontiers in immunology · 2025Trial
- Iron Deficiency Anemia at Time of Vaccination Predicts Decreased Vaccine Response and Iron Supplementation at Time of Vaccination Increases Humoral Vaccine Response: A Birth Cohort Study and a Randomized Trial Follow-Up Study in Kenyan Infants.Frontiers in immunology · 2020Trial
- The measles vaccine's effectiveness during an epidemic: a test negative case control study (Tunisia, 2019).BMC infectious diseases · 2026Article
- Investigation of a measles outbreak in a highly vaccinated middle school, France, 2023.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025Article
- Article
- Long-term Dynamics of Measles Virus-Specific Neutralizing Antibodies in Children Vaccinated Before 12 Months of Age.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- Article
- A literature review and evidence-based evaluation of the Dutch national immunisation schedule yield possibilities for improvements.Vaccine: X · 2024Review
- The Problem with Delaying Measles Elimination.Vaccines · 2024Review
- Breakthrough Measles among Vaccinated Adults Born during the Post-Soviet Transition Period in Mongolia.Vaccines · 2024Article
- Immunogenicity and reactogenicity following MMR vaccination in 5-7-month-old infants: a double-blind placebo-controlled randomized clinical trial in 6540 Danish infants.EClinicalMedicine · 2024Article
- Long-term measles antibody profiles following different vaccine schedules in China, a longitudinal study.Nature communications · 2023Article
- Measles Vaccination Elicits a Polyfunctional Antibody Response, Which Decays More Rapidly in Early Vaccinated Children.The Journal of infectious diseases · 2022Article
- Antibody Levels at 3-Years Follow-Up of a Third Dose of Measles-Mumps-Rubella Vaccine in Young Adults.Vaccines · 2022Article
- The adaptive immune system in early life: The shift makes it count.Frontiers in immunology · 2022Review
- Measles in the 21st Century: Progress Toward Achieving and Sustaining Elimination.The Journal of infectious diseases · 2021Article
- Association between season of vaccination and antibody levels against infectious diseases.Epidemiology and infection · 2020Article
- Elevated expansion of follicular helper T cells in peripheral blood from children with acute measles infection.BMC immunology · 2020Article
- Early Waning of Maternal Measles Antibodies in Infants in Zhejiang Province, China: A Comparison of Two Cross-Sectional Serosurveys.International journal of environmental research and public health · 2019Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe majority of infants will not be protected by maternal antibodies until their first measles vaccination, between 12 and 15 months of age. This provides incentive to reduce the age at measles vaccination, but immunological consequences are insufficiently understood, and long-term effects are largely unknown.
methodsA total of 79 infants who received early measles vaccination between 6 and 12 months age and a second dose at 14 months of age were compared to 44 children in a control group who received 1 dose at 14 months of age. Measles virus-specific neutralizing antibody concentrations and avidity were determined up to 4 years of age.
resultsInfants who first received measles vaccination before 12 months of age had a long-term decrease in the concentration and avidity of measles virus-specific neutralizing antibodies, compared with infants in the control group. For 11.1% of children with a first dose before 9 months of age, antibody levels at 4 years of age had dropped below the cutoff for clinical protection.
conclusionsEarly measles vaccination provides immediate protection in the majority of infants but yields a long-term decrease in neutralizing antibody responses, compared to vaccination at a later age. Additional vaccination at 14 months of age does not improve this. Over the long term, this may result in an increasing number of children susceptible to measles.
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