ArticleActa pharmaceutica Sinica. B2019
Redox-sensitive prodrug nanoassemblies based on linoleic acid-modified docetaxel to resist breast cancers.
Article in Acta pharmaceutica Sinica. B, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- A self-assembled and HTheranostics · 2025Article
- Chemical Reactions in Living Systems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Redox-Responsive Lipidic Prodrug Nano-Delivery System Improves Antitumor Effect of Curcumin Derivative C210.Pharmaceutics · 2023Article
- Multifunctional nanoparticle for cancer therapy.MedComm · 2023Review
- Autophagy responsive intra-intercellular delivery nanoparticles for effective deep solid tumor penetration.Journal of nanobiotechnology · 2022Article
- Bispecific prodrug nanoparticles circumventing multiple immune resistance mechanisms for promoting cancer immunotherapy.Acta pharmaceutica Sinica. B · 2022Article
- Direct comparison of two kinds of linoleic acid-docetaxel derivatives: in vitro cytotoxicity and in vivo antitumor activity.Drug delivery and translational research · 2022Article
- Dynamic Adjust of Non-Radiative and Radiative Attenuation of AIE Molecules Reinforces NIR-II Imaging Mediated Photothermal Therapy and Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Self-Assembly Nanoparticles of Natural Bioactive Abietane Diterpenes.International journal of molecular sciences · 2021Article
- Nano-Drug Design Based on the Physiological Properties of Glutathione.Molecules (Basel, Switzerland) · 2021Review
- Investigating the crucial roles of aliphatic tails in disulfide bond-linked docetaxel prodrug nanoassemblies.Asian journal of pharmaceutical sciences · 2021Article
- In Silico Network Analysis of Ingredients of Cornus officinalis in Osteoporosis.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Intracellular aggregation of peptide-reprogrammed small molecule nanoassemblies enhances cancer chemotherapy and combinatorial immunotherapy.Acta pharmaceutica Sinica. B · 2021Article
- Solubility and biological activity enhancement of docetaxelRSC advances · 2021Article
- Remote loading paclitaxel-doxorubicin prodrug into liposomes for cancer combination therapy.Acta pharmaceutica Sinica. B · 2020Article
- A combination of LightOn gene expression system and tumor microenvironment-responsive nanoparticle delivery system for targeted breast cancer therapy.Acta pharmaceutica Sinica. B · 2020Article
- Oleic Acid Copolymer as A Novel Upconversion Nanomaterial to Make Doxorubicin-Loaded Nanomicelles with Dual Responsiveness to pH and NIR.Pharmaceutics · 2020Article
- Tumor microenvironment responsive drug delivery systems.Asian journal of pharmaceutical sciences · 2020Review
- Dynamic DNA Assemblies in Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Combination Therapy of Lung Cancer Using Layer-by-Layer Cisplatin Prodrug and Curcumin Co-Encapsulated Nanomedicine.Drug design, development and therapy · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prodrug nanoassemblies, which can refrain from large excipients, achieve higher drug loading and control drug release, have been placed as the priority in drug delivery system. Reasoning that glutathione (GSH) and reactive oxygen species (ROS) are highly upgraded in tumor tissues which makes them attractive targets for drug delivery system, we designed and synthetized a novel prodrug which utilized mono thioether bond as a linker to bridge linoleic acid (LA) and docetaxel (DTX). This mono thioether-linked conjugates (DTX-S-LA) could self-assemble into nanoparticles without the aid of much excipients. The mono thioether endowed the nanoparticles redox sensitivity resulting in specific release at the tumor tissue. Our studies demonstrated that the nanoassemblies had uniform particle size, high stability and fast release behavior. DTX-S-LA nanoassemblies outperformed DTX solution in pharmacokinetic profiles for it had longer circulation time and higher area under curve (AUC). Compared with DTX solution, the redox dual-responsive nanoassemblies had comparable cytotoxic activity. Besides, the antitumor efficacy was evaluated in mice bearing 4T1 xenograft. It turned out this nanoassemblies could enhance anticancer efficacy by increasing the dose because of higher tolerance. Overall, these results indicated that the redox sensitivity nanoassemblies may have a great potential to cancer therapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.