Evidence map›Paper›PMID 30972284›Full record

ArticleActa pharmaceutica Sinica. B2019

Dual-targeting and microenvironment-responsive micelles as a gene delivery system to improve the sensitivity of glioma to radiotherapy.

Xiuxiu Jiao, Yuan Yu, Jianxia Meng, Mei He, Charles Jian Zhang, Wenqian Geng, Baoyue Ding, Zhuo Wang, Xueying Ding

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Xiuxiu JiaoDepartment of Pharmaceutics, Shanghai General Hospital, Shanghai Jiao Tong University of Medicine, Shanghai 200080, China.
Yuan YuDepartment of Pharmaceutical Sciences, School of Pharmacy, Second Military Medical University, Shanghai 200082, China.
Jianxia MengDepartment of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200082, China.
Mei HeDepartment of Pharmaceutics, Shanghai General Hospital, Shanghai Jiao Tong University of Medicine, Shanghai 200080, China.
Charles Jian ZhangDepartment of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91768, USA.
Wenqian GengDepartment of Pharmaceutics, Shanghai General Hospital, Shanghai Jiao Tong University of Medicine, Shanghai 200080, China.
Baoyue DingDepartment of Pharmaceutics, College of Medicine, Jiaxing University, Jiaxing 314000, China.
Zhuo WangDepartment of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200082, China.
Xueying DingDepartment of Pharmaceutics, Shanghai General Hospital, Shanghai Jiao Tong University of Medicine, Shanghai 200080, China.
Second Military Medical University · CNShanghai First People's Hospital · CNShanghai Jiao Tong University · CNJiaxing University · CNWestern University of Health Sciences · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dbait is a small double-stranded DNA molecule that has been utilized as a radiosensitizer to enhance the sensitivity of glioma to radiotherapy (RT). However, there is no effective drug delivery system to effectively overcome the blood-brain barrier (BBB). The aim of this study was to develop a gene delivery system by using the BBB and glioma dual-targeting and microenvironment-responsive micelles (ch-K

Indexed as

Arg, arginineATCC, American Type Culture CollectionBBB, blood–brain barrierBBTB, blood—brain tumor barriersCell-penetrating peptidesch-KnR8-An, the non-cross-linked cholesterol-polylysine-polyarginine peptide core-shell polymer micelles modified with angiopep-2, n = 3, 5, 7ch-Kn(s-s)R8-An, the disulfide cross-linked cholesterol-polylysine-polyarginine peptide core-shell polymer micelles modified with angiopep-2, n = 3, 5, 7CMC, critical micelle concentrationDTSSP, 3,3′-dithiobis(sulfosuccinimidylpropionate)DTT, dithiothreitolFBS, fetal bovine serumGBM, glioblastoma multiformeGene deliveryGlioma-targetingGSH, glutathioneKnR8, cholesterol-polylysine-polyarginine peptide, n = 3, 5, 7Lys, lysineMicroenvironment-responsive micellesMMP-2, matrix metalloproteinase 2MWCO, molecular weight cutoffPDI, polydispersity indexpDNA, plasmid DNAPEI, polyethyleniminePE, plating efficiencyRadiosensitizerRT, radiotherapy

Identifiers

PMID30972284
PMCPMC6437633
OpenAlexW2904372638

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.