ArticleJournal of pathology informatics2019
Validation of Whole-slide Digitally Imaged Melanocytic Lesions: Does Z-Stack Scanning Improve Diagnostic Accuracy?
Article in Journal of pathology informatics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Artificial intelligence in cytopathological applications for cancer: a review of accuracy and analytic validity.European journal of medical research · 2024Pooled it
- Technical and Diagnostic Issues in Whole Slide Imaging Published Validation Studies.Frontiers in oncology · 2022Pooled it
- Perceptions of digital pathology among healthcare workers in pathology.Journal of pathology informatics · 2026Article
- "Assessment of an EMR-integrated Onco-Insight hospital-based cancer registry system for data completeness and data entry turnaround time at a tertiary care cancer center in India".Frontiers in oncology · 2026Article
- Computer-Aided Assessment of Melanocytic Lesions by Means of a Mitosis Algorithm.Diagnostics (Basel, Switzerland) · 2022Article
- Validation of digital microscopy: Review of validation methods and sources of bias.Veterinary pathology · 2022Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccurate diagnosis of melanocytic lesions is challenging, even for expert pathologists. Nowadays, whole-slide imaging (WSI) is used for routine clinical pathology diagnosis in several laboratories. One of the limitations of WSI, as it is most often used, is the lack of a multiplanar focusing option. In this study, we aim to establish the diagnostic accuracy of WSI for melanocytic lesions and investigate the potential accuracy increase of z-stack scanning. Z-stack enables pathologists to use a software focus adjustment, comparable to the fine-focus knob of a conventional light microscope. MATERIALS AND
methodsMelanocytic lesions (
resultsAn expert consensus diagnosis was achieved in 99 (97%) of cases. Concordance rates between surgical pathologists and the ground truth varied between 75% and 90%, excluding nevoid melanoma cases. Concordance rates of nevoid melanoma varied between 10% and 80%. Pathologists used the software focusing option in 7%-28% of cases, which in 1 case of nevoid melanoma resulted in correcting a misdiagnosis after finding a dermal mitosis.
conclusionDiagnostic accuracy of melanocytic lesions based on glass slides and WSI is comparable with previous publications. A large variability in diagnostic accuracy of nevoid melanoma does exist. Our results show that z-stack scanning, in general, does not increase the diagnostic accuracy of melanocytic.
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