ArticleBiomedical reports2019
Effect of aging on the tendon structure and tendon-associated gene expression in mouse foot flexor tendon.
Article in Biomedical reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- SIRT3-dependent mitochondrial redox homeostasis protects against age-related tendon degeneration.Bone & joint research · 2026Article
- Loss of type III collagen has limited effect on tendon healing in young adult mice.Matrix biology : journal of the International Society for Matrix Biology · 2026Article
- Beyond local injury: pathogenic roles of metabolic, endocrine, and aging-associated systemic factors in tendinopathy and novel therapeutic strategies.Journal of orthopaedic surgery and research · 2026Review
- The myodural bridge complex: a comprehensive review of morphology, physiology, developmental biology and pathology.Frontiers in medicine · 2026Review
- Functional Outcomes of Proximal Hamstring Tendon Repair in Patients Over 40 Treated Without Postoperative Bracing.Orthopaedic journal of sports medicine · 2025Article
- Tendon Tissue Engineering: Pathophysiological Mechanism and Bioengineering Therapy of Tendinopathy.International journal of nanomedicine · 2025Review
- Adeno-Associated Virus-Delivered Fibroblast Growth Factor 18 Gene Therapy Promotes Cartilage Anabolism.Cartilage · 2023Article
- Effect of Aging on Tendon Biology, Biomechanics and Implications for Treatment Approaches.International journal of molecular sciences · 2023Review
- Decoding the transcriptomic expression and genomic methylation patterns in the tendon proper and its peritenon region in the aging horse.BMC research notes · 2023Article
- Aging and injury affect nuclear shape heterogeneity in tendon.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Animal model for tendinopathy.Journal of orthopaedic translation · 2023Review
- Optogenetic-induced muscle loading leads to mechanical adaptation of the Achilles tendon enthesis in mice.Science advances · 2023Article
- Nanoscale vibration could promote tenogenic differentiation of umbilical cord mesenchymal stem cells.In vitro cellular & developmental biology. Animal · 2023Article
- Optogenetic-Induced Muscle Loading Leads to Mechanical Adaptation of the Achilles Tendon Enthesis in Mice.bioRxiv : the preprint server for biology · 2023Article
- Article
- Impact of aging on tendon homeostasis, tendinopathy development, and impaired healing.Connective tissue research · 2023Review
- The Effect of Age and Intrinsic Aerobic Exercise Capacity on the Expression of Inflammation and Remodeling Markers in Rat Achilles Tendons.International journal of molecular sciences · 2021Article
- Picrosirius Red Staining: Revisiting Its Application to the Qualitative and Quantitative Assessment of Collagen Type I and Type III in Tendon.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2021Article
- Advanced Glycation End Products Are Retained in Decellularized Muscle Matrix Derived from Aged Skeletal Muscle.International journal of molecular sciences · 2021Article
- The combined effects of obesity and ageing on skeletal muscle function and tendon properties in vivo in men.Endocrine · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To evaluate the biological changes in tendons during the aging process, the present study examined the effect of aging on the tendon structure, distribution of collagen types I and III, and expression of tendon-associated genes, using flexor tendons in a mouse model. Histological assessment of the tendon structure and distribution of collagen types I and III were performed, and the expression of tendon-associated genes was evaluated in flexor digitorium longus tendons of young (8 weeks) and aged (78 weeks) female C57BL/6 mice. The results indicated that the Soslowsky score, based on the analysis of cellularity, fibroblastic changes, and collagen fiber orientation and disruption, was significantly increased, or worsened, in the tendons of the aged group compared with those in the young group. Furthermore, in the aged group, the distribution of type I collagen was decreased and the distribution of type III collagen was relatively increased compared with the young group. Finally, the mRNA expression levels of collagen (type I and type III) and tenogenic markers (Mohawk homeobox, tenomodulin and scleraxis BHLH transcription factor) were significantly decreased in the aged group compared with the young group. The present observations demonstrated that the structure of the tendons, distribution of types I and III collagen and the expression of tendon-associated genes were modulated by aging in the flexor tendon, and that these changes may contribute to the degeneration of tendons in tendinopathy.
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