Evidence map›Paper›PMID 30972210›Full record

ArticleAmerican journal of translational research2019

Treatment selection of recurrent hepatocellular carcinoma with microvascular invasion at the initial hepatectomy.

Han Xiao, Ze-Bin Chen, Hui-Lin Jin, Bin Li, Li-Xia Xu, Yu Guo, Shu-Ling Chen, He-Ping Li, Zhen-Wei Peng, Jing-Xian Shen

Abstract read
In one paragraph

Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Han XiaoDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080, China.
Ze-Bin ChenDepartment of Liver Surgery, The First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080, China.
Hui-Lin JinDepartment of Liver Surgery, The First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080, China.
Bin LiClinical Trials Unit, The First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080, China.
Li-Xia XuDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080, China.
Yu GuoDepartment of General Surgery, The First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080, China.
Shu-Ling ChenDivision of Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080, China.
He-Ping LiDepartment of Oncology, The First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080, China.
Zhen-Wei PengClinical Trials Unit, The First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080, China.
Jing-Xian ShenDepartment of Medical Imaging, Sun Yat-sen University Cancer Center 651 Dongfeng Road East, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecurrent hepatocellular carcinoma (rHCC) patients with microvascular invasive (MVI) positive at first resection usually had poorly differentiated tumors and worse survivals. The optimal treatment for this population remains to be elucidated.

methodsWe retrospectively analyzed 319 rHCC patients with MVI-positive at first resection from June, 2009 to June, 2017. Survival and costs between curative treatments [re-resection (RR) and radiofrequency ablation (RFA)] and transarterial chemoembolization (TACE) were compared. Subgroup comparisons were made in patients in Barcelona Clinic Liver Cancer (BCLC) stage 0-A and BCLC stage B-C, respectively. A one-to-one propensity score matching (PSM) was used to diminish bias.

resultsIn BCLC stage 0-A, 98 received RR/RFA, and 49 received TACE. The median overall survival (OS) of RR/RFA group was not reached, while the OS of TACE group was 26.3 months (

conclusionRR/RFA provided better survival outcomes for rHCC patients with MVI-positive at first resection in selected BCLC stage 0-A. In selected BCLC stage B-C, TACE shared a similar efficacy with RR and RFA but a lower cost than RR.

Indexed as

catheter ablationhepatectomyHepatocellular carcinomarecurrencetherapeutic chemoembolization

Identifiers

PMID30972210
PMCPMC6456518

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.