Evidence map›Paper›PMID 30972165›Full record

ArticleAmerican journal of translational research2019

Chemerin stimulates aortic smooth muscle cell proliferation and migration via activation of autophagy in VSMCs of metabolic hypertension rats.

Juan Wen, Jiajie Wang, Lan Guo, Weijun Cai, Yang Wu, Wei Chen, Xiaohong Tang

Open access · greenAbstract read
In one paragraph

Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
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  7. Chemerin is resident to vascular tunicas and contributes to vascular tone.American journal of physiology. Heart and circulatory physiology · 2023
    Article
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  19. Novel Targets for Hypertension Drug Discovery.Current hypertension reports · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Juan WenDepartment of Cardiology of The Third Xiangya Hospital, Central South University Changsha, China.
Jiajie WangDepartment of Histology and Embryology, School of Basic Medicine, Central South University Changsha, Hunan, China.
Lan GuoDepartment of Cardiology of The Third Xiangya Hospital, Central South University Changsha, China.
Weijun CaiDepartment of Histology and Embryology, School of Basic Medicine, Central South University Changsha, Hunan, China.
Yang WuDepartment of Cardiology of The Third Xiangya Hospital, Central South University Changsha, China.
Wei ChenDepartment of Cardiology of The Third Xiangya Hospital, Central South University Changsha, China.
Xiaohong TangDepartment of Cardiology of The Third Xiangya Hospital, Central South University Changsha, China.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular remodeling is a characteristic pathogenesis of hypertension and a main cause of abnormal construction and function of organs because of hypertension. Chemerin is a new adipokine that is elevated in states of obesity and metabolic syndrome (MS). However, the molecular mechanisms behind these pathological processes are not fully clarified. An animal model of metabolic hypertension was created to evaluate the role of metabolic chemerin in hypertension. In this study, the expression of chemerin/CMKLR-1 and autophagy in the arteries of metabolic hypertension rats undergoing vascular remodeling was investigated and the effect and mechanisms on the regulation of human aortic smooth muscle cells (HA-SMCs) were explored. The vascular remodeling

Indexed as

autophagyBlood pressurechemerinmetabolic hypertensionvascular remodeling

Identifiers

PMID30972165
PMCPMC6456550
OpenAlexW2988394081

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.