ReviewAmerican journal of translational research2019
Potential role of exosomes in the pathophysiology, diagnosis, and treatment of hypoxic diseases.
Review in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 53 citations in OpenAlex.
- Research progress on biomarkers of traumatic brain injury.Animal models and experimental medicine · 2026Review
- Extracellular Vesicles and Immune Activation in Solid Organ Transplantation: The Impact of Immunosuppression.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2025Review
- Exosomes in Osteoarthritis: A Review on Their Isolation Techniques and Therapeutic Potential.Indian journal of orthopaedics · 2024Review
- Stem cells-derived exosomes as cardiac regenerative agents.International journal of cardiology. Heart & vasculature · 2024Review
- Review
- Impact of hypoxia on the molecular content of glioblastoma-derived exosomes.Extracellular vesicles and circulating nucleic acids · 2024Review
- New Insights into Cardiovascular Diseases Treatment Based on Molecular Targets.International journal of molecular sciences · 2023Review
- Nanoscopic and Functional Characterization of Keratinocyte-Originating Exosomes in the Wound Fluid of Non-Diabetic and Diabetic Chronic Wound Patients.Nano today · 2023Article
- Small Cellular Particles from European Spruce Needle Homogenate.International journal of molecular sciences · 2023Article
- Role of hypoxic exosomes and the mechanisms of exosome release in the CNS under hypoxic conditions.Frontiers in neurology · 2023Review
- The role of TNF-α in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironment.Frontiers in immunology · 2023Review
- Physiopathological role of extracellular vesicles in alloimmunity and kidney transplantation and their use as biomarkers.Frontiers in immunology · 2023Review
- Exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases.Drug delivery and translational research · 2022Review
- Hypoxia-induced HIF1α activation regulates small extracellular vesicle release in human embryonic kidney cells.Scientific reports · 2022Article
- Current perspectives on clinical use of exosomes as novel biomarkers for cancer diagnosis.Frontiers in oncology · 2022Review
- Extracellular vesicles: Targeting the heart.Frontiers in cardiovascular medicine · 2022Review
- Stem Cell-Derived Extracellular Vesicles as Potential Therapeutic Approach for Acute Kidney Injury.Frontiers in immunology · 2022Review
- Small Extracellular Vesicles from Head and Neck Squamous Cell Carcinoma Cells Carry a Proteomic Signature for Tumor Hypoxia.Cancers · 2021Article
- The role of PD-L1 in the immune dysfunction that mediates hypoxia-induced multiple organ injury.Cell communication and signaling : CCS · 2021Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exosomes are extracellular vesicles that originate in the endosomal system. They perform important functions for cell-to-cell communication by transferring bioactive cargoes to recipient cells or activating signal transduction pathways in the target cells. Hypoxia is a severe cellular stress that can regulate the release of exosomes and change their contents. Exosomes have been investigated in different types of hypoxic diseases and found to have many effects from pathology to protection. Increasingly, studies have indicated that exosomes can reflect their cellular origin and disease state through the bioactive cargoes they carry, making exosomes useful as potential biomarkers for diagnosing or predicting hypoxic diseases. In this review, we summarize the effects and mechanisms of hypoxia on exosomes and introduce the basics of exosome production, release, and uptake. In addition, we also summarize current information on the involvement, diagnostic value, and therapeutic potential of exosomes in different types of hypoxic diseases, including myocardial infarction (MI), renal ischemia-reperfusion (IR) induced acute kidney injury (AKI) and hypoxic tumors.
Indexed as
Identifiers
30972155PMC6456517W2991442784What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.