Evidence map›Paper›PMID 30972068›Full record

ReviewFrontiers in immunology2019

New Paradigm in the Role of Regulatory T Cells During Pregnancy.

Sayaka Tsuda, Akitoshi Nakashima, Tomoko Shima, Shigeru Saito

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06281262 (The Role of Selected Immunological Indicators and Microbiota in Patients Experiencing Premature Birth and Preeclampsia), which is not on this map. Cited by 97 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 2 pooled it
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06281262 unknown statusnot on this mapstarted 2023, after this paper: background citation

The Role of Selected Immunological Indicators and Microbiota in Patients Experiencing Premature Birth and Preeclampsia

TypeobservationalSponsorGeneral University Hospital, PragueRan2023 to 2025Enrolled100ConditionsPreterm Birth, PreeclampsiaArmsPeripheral blood collection, Swab sample collection
3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 2 syntheses or guidelines pooled it, 170 citations in OpenAlex.

  1. Advances in pathogenesis of preeclampsia.Archives of gynecology and obstetrics · 2024
    Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Impact of Maternal Immune Response on Oral Health and Pregnancy Outcomes.Advances in experimental medicine and biology · 2026
    Review
  7. Review
  8. Review
  9. Single-cell-level digital twins for preterm birth prevention strategies.bioRxiv : the preprint server for biology · 2025
    Article
  10. The High Frequency of a G-Allele Variant of theAnimals : an open access journal from MDPI · 2025
    Article
  11. Regulatory KIRScience translational medicine · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sayaka TsudaDepartment of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.
Akitoshi NakashimaDepartment of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.
Tomoko ShimaDepartment of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.
Shigeru SaitoDepartment of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.
University of Toyama · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Semi-allogenic fetuses are not rejected by the maternal immune system because feto-maternal tolerance induced by CD4

Indexed as

AnimalsFemaleFetusHumansImmune ToleranceKiller Cells, NaturalMicePregnancyPregnancy ComplicationsT-Lymphocytes, Regulatorymiscarriagepreeclampsiapregnancyregulatory T cellsseminal plasma

Identifiers

PMID30972068
PMCPMC6443934
OpenAlexW2923054902

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.