Evidence map›Paper›PMID 30971898›Full record

ArticleFrontiers in cellular neuroscience2019

Semaphorin 3A Contributes to Secondary Blood-Brain Barrier Damage After Traumatic Brain Injury.

Mengchen Yang, Xiaoxue Wang, Yueshan Fan, Yaqing Chen, Dongdong Sun, Xin Xu, Jianhao Wang, Gang Gu, Ruilong Peng, Tianyu Shen and 11 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

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  13. Aging and CNS Myeloid Cell Depletion Attenuate Breast Cancer Brain Metastasis.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 3 institutions in 1 country.

Mengchen YangDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Xiaoxue WangTianjin Medical University, Tianjin, China.
Yueshan FanDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Yaqing ChenTianjin Medical University, Tianjin, China.
Dongdong SunDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Xin XuDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Jianhao WangDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Gang GuDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Ruilong PengDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Tianyu ShenTianjin Medical University, Tianjin, China.
Xilei LiuDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Fanjian LiDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Yi WangDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Dong WangDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Hongtao RongDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Zhenying HanDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Xiangliang GaoDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Qifeng LiDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Keyuan FanTianjin Chest Hospital, Tianjin, China.
Yuhua YuanTianjin Medical University, Tianjin, China.
Jianning ZhangDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Tianjin Medical University · CNTianjin Medical University General Hospital · CNTianjin Chest Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Semaphorin 3A (SEMA3A) is a member of the Semaphorins family, a class of membrane-associated protein that participates in the construction of nerve networks. SEMA3A has been reported to affect vascular permeability previously, but its influence in traumatic brain injury (TBI) is still unknown. To investigate the effects of SEMA3A, we used a mouse TBI model with a controlled cortical impact (CCI) device and a blood-brain barrier (BBB) injury model

Indexed as

blood–brain barriermiRNA-30b-5poxygen-glucose deprivationSemaphorin 3Atraumatic brain injury

Identifiers

PMID30971898
PMCPMC6444306
OpenAlexW2924629321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.