ArticleNature2019
p38γ is essential for cell cycle progression and liver tumorigenesis.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 95 citations in OpenAlex.
- p38γ and p38δ MAP kinases in inflammation.Biochemical Society transactions · 2026Review
- Synergistic effects and molecular mechanisms of pirfenidone combined with EGFR-TKIs in non-small cell lung cancer.Translational lung cancer research · 2026Article
- Comparative effects of semaglutide tirzepatide and retatrutide on renal fibrosis in UUO and aged mice.iScience · 2026Article
- Review
- Hepatic p38γ exacerbates acetaminophen‑induced acute liver injury via PI3K/Akt‑dependent mechanisms.International journal of molecular medicine · 2026Article
- The evolving landscape of CDK inhibitor use in breast cancer therapy and beyond.Nature reviews. Drug discovery · 2026Review
- P38γ drives aerobic glycolysis in liver sinusoidal endothelial cells and regulates alcoholic liver disease via the PFKFB3 signaling pathway.Molecular biology reports · 2026Article
- Homeobox A10 in gastrointestinal malignancies: unraveling metastatic mechanisms and novel therapeutic opportunities.Cancer metastasis reviews · 2026Review
- Blocking acid-sensing ion channel 1a attenuates bilirubin-induced ototoxicity in cochlear organotypic culture.Fundamental research · 2026Article
- Leveraging AI and Natural Compounds: Innovative Approaches in the Diagnosis and Treatment of Hepatocellular Carcinoma.Current pharmaceutical design · 2026Review
- Particulate matter increases bone morphogenetic protein 2 in lung fibroblasts.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- Deep learning facilitated discovery of prognosis biomarkers and their ligands to improve liver cancer treatment.International journal of surgery (London, England) · 2026Article
- Targeting the MAPK Pathway in Cancer.International journal of molecular sciences · 2025Review
- Application of Pirfenidone-loaded Fluorescence Nanoparticles to Inhibit Hepatocellular Carcinoma by Modulating Oxidative Stress.Journal of fluorescence · 2025Article
- Liver regeneration-associated hepatocellular YAP1 activation prevents colorectal cancer liver metastasis through glutamine competition.Science advances · 2025Article
- Article
- Synthetic essentiality of TRAIL/TNFSF10 in VHL-deficient renal cell carcinoma.bioRxiv : the preprint server for biology · 2025Article
- The Novel Prognostic Biomarker MAPK12 Promotes Migration, Proliferation, and Invasion in Head and Neck Squamous Cell Carcinoma.Current medicinal chemistry · 2025Article
- Repurposing Nilotinib as a Selective P38β Inhibitor in Hematopoietic Malignancies: Clinical Evidence and Mechanistic Insights.Journal of clinical haematology · 2025Article
- A retrospective analysis of the clinicopathological features and prognostic value of MAPK12 protein expression in diffuse large B-cell lymphoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors at 11 institutions in 3 countries.
Antonia Tomás-LobaCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Elisa Manieri *Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Bárbara González-Terán *Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Alfonso MoraCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Luis Leiva-VegaCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Ayelén M SantamansCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Rafael Romero-BecerraCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Elena RodríguezCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Aránzazu Pintor-ChocanoCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Ferran FeixasDepartament de Química and Institut de Química Computacional i Catàlisi, Universitat de Girona, Girona, Spain.
Juan Antonio LópezCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Beatriz CaballeroCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Marianna TrakalaCentro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.
Óscar BlancoUniversity of Salamanca, University Hospital of Salamanca-IBSAL, Salamanca, Spain.
Jorge L TorresUniversity of Salamanca, University Hospital of Salamanca-IBSAL, Salamanca, Spain.
Lourdes Hernández-CosidoUniversity of Salamanca, University Hospital of Salamanca-IBSAL, Salamanca, Spain.
Valle Montalvo-RomeralCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Nuria MatesanzCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Marta Roche-MolinaCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Juan Antonio BernalCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Hannah MischoSir William Dunn School of Pathology, Oxford University, Oxford, UK.
Marta LeónCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Ainoa CaballeroCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Diego Miranda-SaavedraCentro de Biología Molecular Severo Ochoa, CSIC/Universidad Autónoma de Madrid, Madrid, Spain.
Jesús Ruiz-CabelloCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Yulia A NevzorovaUniversity Hospital RWTH Aachen, Aachen, Germany.
Francisco Javier CuberoComplutense University School of Medicine, Madrid, Spain.
Jerónimo BravoInstituto de Biomedicina de Valencia, IBV-CSIC, Valencia, Spain.
Jesús VázquezCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Marcos MalumbresCentro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.
Miguel MarcosUniversity of Salamanca, University Hospital of Salamanca-IBSAL, Salamanca, Spain.
Sílvia OsunaDepartament de Química and Institut de Química Computacional i Catàlisi, Universitat de Girona, Girona, Spain.
Guadalupe SabioCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. gsabio@cnic.es.
Spanish National Centre for Cardiovascular Research · ESInstituto de Investigación Biomédica de Salamanca · ESUniversidad Complutense de Madrid · ESUniversidad de Salamanca · ESUniversity of Girona · ESCentro de Investigación en Red en Enfermedades Cardiovasculares · ESCentro Nacional de Epidemiología · ESInstituto de Biomedicina de Valencia · ESSpanish National Cancer Research Centre · ESUniversidad Autónoma de Madrid · ESUniversity of Oxford · GB
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cell cycle is a tightly regulated process that is controlled by the conserved cyclin-dependent kinase (CDK)-cyclin protein complex
Indexed as
Cell CycleAgedAnimalsCarcinogenesisCarcinoma, HepatocellularCell Line, TumorCyclin-Dependent KinasesFemaleHepatocytesHumansLiverLiver NeoplasmsMaleMiceMiddle AgedMitogen-Activated Protein Kinase 12Cyclin-Dependent KinasesMitogen-Activated Protein Kinase 12pirfenidonePyridonesRetinoblastoma Protein
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.