ArticleNature2019
Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET.
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Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers.
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151citing papers in PubMed
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Who cites it
151 citing papers in PubMed.
- Trial
- Article
- HIV-1 Env Heterogeneity: Cleavage, Trafficking, and Antigenic Consequences for Virions and Infected Cells.Viruses · 2026Review
- INAAC: An affinity chromatography strategy enabling characterization and quantification of influenza neuraminidase antigens in vaccines.The Journal of biological chemistry · 2026Article
- Endocytic motif on HIV-1 Env regulates cleavage status and antibody neutralization of cell-free and cell-to-cell infection.Journal of virology · 2026Article
- Structural and dynamic insights into SPDT for phosphorus allocation in rice.Science China. Life sciences · 2026Article
- A tissue-intrinsic mechanism sensitizes HIV-1 particles for TLR-triggered innate immune responses.Nature communications · 2026Article
- Conformational landscape of HIV-1 Env from closed to fully open.Nature communications · 2026Article
- Conformational dynamics of the HIV-1 envelope glycoprotein from CRF01_AE is associated with susceptibility to antibody-dependent cellular cytotoxicity.Journal of virology · 2026Article
- Integrating Molecular Dynamics Simulations and Single-molecule FRET Spectroscopy: From Computational FRET Estimation to Experimental Data Interpretation.The journal of physical chemistry. B · 2026Review
- Structure of HIV-1 Env glycoprotein on virions reveals an alternative fusion subunit organization and native membrane coupling.bioRxiv : the preprint server for biology · 2026Article
- The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC.Nature communications · 2025Article
- An engineered antibody-lectin conjugate targeting the HIV glycan shield protects humanized mice against HIV challenge.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Conformational trajectory of the HIV-1 fusion peptide during CD4-induced envelope opening.Nature communications · 2025Article
- A gp41 HR2 residue modulates the susceptibility of HIV-1 envelope glycoproteins to small molecule inhibitors targeting gp120.Journal of virology · 2025Article
- AFM for Studying the Functional Activity of Enzymes.Biomolecules · 2025Review
- Article
- The membrane-proximal external region of human immunodeficiency virus (HIV-1) envelope glycoprotein trimers in A18-lipid nanodiscs.Communications biology · 2025Article
- Review
- Genetic Code Expansion: Recent Developments and Emerging Applications.Chemical reviews · 2025Review
91 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
30 authors.
Maolin LuDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.
Xiaochu MaDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.
Luis R Castillo-MenendezDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
Jason GormanVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Nirmin AlsahafiDepartment of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada.
Utz ErmelDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.
Daniel S TerryDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
Michael ChambersVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Dongjun PengVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Baoshan ZhangVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Tongqing ZhouVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Nick ReichardDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.
Kevin WangDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.
Jonathan R GroverDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.
Brennan P CarmanDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.
Matthew R GardnerDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, USA.
Ivana Nikić-SpiegelWerner Reichardt Centre for Integrative Neuroscience, University of Tuebingen, Tuebingen, Germany.
Akihiro SugawaraDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA, USA.
James ArthosLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Edward A LemkeDepartments of Biology and Chemistry, Pharmacy and Geosciences, Johannes Gutenberg University Mainz, Mainz, Germany.
Amos B SmithDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA, USA.
Michael FarzanDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, USA.
Cameron AbramsDepartment of Chemical and Biological Engineering, Drexel University, Philadelphia, PA, USA.
James B MunroDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA.
Adrian B McDermottVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Andrés FinziDepartment of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada.
Peter D KwongVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Scott C BlanchardDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA. scb2005@med.cornell.edu.
Joseph G SodroskiDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA. Joseph_Sodroski@dfci.harvard.edu.
Walther MothesDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA. walther.mothes@yale.edu.
Funding
Virus biology scientific research support componentUM1AI100645 · NIAID · DUKE UNIVERSITY · PI MCMICHAEL, ANDREW JAMES · 2012 to 2018
$204.7MVaccine Immunology ProgramZIAAI005143 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KOUP, RICHARD A · 2019 to 2025
$51.8MUnderstanding Envelope Function in HIV-1 Infection: The Design, Synthesis and Validation of Small Molecule HIV-1 Env InhibitorsP01GM056550 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI ABRAMS, CAMERON F · 1997 to 2018
$31.2MCell and Gene Therapy for HIV CureUM1AI126623 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI JEROME, KEITH R, KIEM, HANS-PETER · 2016 to 2020
$24.2MMechanisms Of Humoral EvasionZIAAI005023 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI ZHOU, TONGQING · 2009 to 2025
$18.6MInteraction of HIV envelope with cell surface receptorsZIAAI000883 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI ARTHOS, JAMES L · 2009 to 2024
$14.0MConformational Landscape of the HIV-1 Envelope GlycoproteinsR01AI124982 · NIAID · DANA-FARBER CANCER INST · PI SODROSKI, JOSEPH G · 2016 to 2025
$6.7MOptimizing eCD4-Ig for eradication and a functional cureR01AI129868 · NIAID · UNIVERSITY OF FLORIDA · PI FARZAN, MICHAEL R. · 2017 to 2021
$5.2MRational Immunogen Design Using Computational MethodsZICAI005114 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI RAWI, REDA · 2010 to 2025
$4.3MNext-generation Fluorescent Probes for Biological ResearchR01GM098859 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI BLANCHARD, SCOTT C · 2012 to 2019
$2.9MEnrichment of the State-1 Conformation of the HIV-1 Envelope GlycoproteinR01AI145547 · NIAID · DANA-FARBER CANCER INST · PI SODROSKI, JOSEPH G · 2019 to 2021
$2.2MSingle molecule imaging of HIV-1 entryR01GM116654 · NIGMS · YALE UNIVERSITY · PI MOTHES, WALTHER H · 2015 to 2018
$1.6MNIAID NIH HHS K22 AI116262NIAID NIH HHS R01 AI124982NIAID NIH HHS R01 AI129868NIAID NIH HHS R01 AI145547NIAID NIH HHS UM1 AI100645NIAID NIH HHS UM1 AI126623NIGMS NIH HHS P01 GM056550NIGMS NIH HHS R01 GM098859NIGMS NIH HHS R01 GM116654
Abstract
The HIV-1 envelope glycoprotein (Env) trimer mediates cell entry and is conformationally dynamic
Indexed as
Fluorescence Resonance Energy TransferSingle Molecule ImagingAnimalsAntibodies, NeutralizingCattleDisulfidesenv Gene Products, Human Immunodeficiency VirusHEK293 CellsHIV-1HumansModels, MolecularMutationProtein ConformationProtein MultimerizationProtein StabilityAntibodies, NeutralizingDisulfidesenv Gene Products, Human Immunodeficiency Virusgp140 envelope protein, Human immunodeficiency virus 1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.