ArticleEye (London, England)2019
Correlation between structural progression in glaucoma and obstructive sleep apnea.
Article in Eye (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- The Pathophysiological Association Between Obstructive Sleep Apnea and Glaucoma: A Current Update.Journal of clinical medicine · 2026Review
- Functional crosstalk between the lung and eye: a new frontier in chronic lung diseases.Archives of toxicology · 2025Review
- The Overlooked Floppy Eyelid Syndrome: From Diagnosis to Medical and Surgical Management.Diagnostics (Basel, Switzerland) · 2024Review
- Ocular Inflammation and Oxidative Stress as a Result of Chronic Intermittent Hypoxia: A Rat Model of Sleep Apnea.Antioxidants (Basel, Switzerland) · 2024Article
- Investigating the Causal Relationship Between Sleep Behaviors and Primary Open-Angle Glaucoma: A Bidirectional Two-Sample Mendelian Randomization Study.Nature and science of sleep · 2024Article
- Association Between Vision-Related Functional Burden and Sleep Disorders in Adults Aged 20 and Over in the United States.Translational vision science & technology · 2023Article
- Primary open-angle glaucoma in patients with obstructive sleep apnoea in a Colombian population: a cross-sectional study.BMJ open · 2023Article
- The Need for Glaucoma Management in Glaucoma Patients with Concurrent Obstructive Sleep Apnea: A Population-Based Cohort Study.Biomedicines · 2023Article
- Glaucoma Is Associated with the Risk of Obstructive Sleep Apnea: A Population-Based Nationwide Cohort Study.Diagnostics (Basel, Switzerland) · 2022Article
- Association of sleep behaviour and pattern with the risk of glaucoma: a prospective cohort study in the UK Biobank.BMJ open · 2022Article
- Increased risk of open-angle glaucoma in non-smoking women with obstructive pattern of spirometric tests.Scientific reports · 2022Article
- A Narrative Review of the Association between Obstructive Sleep Apnea and Glaucoma in Adults.International journal of molecular sciences · 2022Review
- Sleep and eye disease: A review.Clinical & experimental ophthalmology · 2022Review
- 7,8-Dihydroxyflavone protects retinal ganglion cells against chronic intermittent hypoxia-induced oxidative stress damage via activation of the BDNF/TrkB signaling pathway.Sleep & breathing = Schlaf & Atmung · 2022Article
- Evaluation of retinal nerve fiber layer, ganglion cell layer, and optic nerve head morphological parameters in patients with obstructive sleep apnea and comparison with normal population.Indian journal of ophthalmology · 2022Article
- Prospective evaluation of the comorbidity of obstructive sleep apnea in patients with glaucoma.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Association of self-reported snoring with decreased retinal thickness and vessel density.Frontiers in physiology · 2022Article
- Neuro-Ophthalmological Manifestations of Obstructive Sleep Apnea: Current Perspectives.Eye and brain · 2020Review
- Prevalence Rates and Risk Factors for Primary Open Angle Glaucoma in the Middle East.Journal of ophthalmic & vision researchReview
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
BACKGROUND/
objectivesTo investigate the correlation between obstructive sleep apnea (OSA) severity and the structural and functional progression in patients with glaucoma. SUBJECTS/
methodsThis retrospective comparative cohort study included subjects from the polysomnography database in Chang Gung Memorial Hospital between June 1, 2009, and June 1, 2017, by identifying patients who had received diagnoses of primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), or glaucoma suspect. Patients with follow-up time of <3 years and/or <3 consecutive reliable optical coherence tomography (OCT) or visual field (VF) tests were excluded. Progression of overall peripapillary retinal nerve fiber layer (RNFL) thickness on OCT scans and VF mean deviation (MD) or VF index (VFI) were determined through linear regression trend analysis.
resultsThirty-two patients were included. There was a trend to higher percentage of progression on RNFL thickness and VF in higher OSAS severity. After stratifying patients to no OSA/mild OSA (group 1) and moderate/severe OSA (group 2), group 2 exhibited a significantly higher percentage of RNFL thickness progression than did group 1 (64.7% vs 26.7%, P = 0.042). Multivariate Cox regression analysis showed that severe OSA had an 8.448-fold higher risk of RNFL thickness progression after age, sex, diabetes mellitus, hypertension, hyperlipidemia, and body mass index adjustment (95% confidence interval, 1.464-48.752, P = 0.017).
conclusionsSevere OSA is significantly correlated with a higher risk of structural deterioration in patients with glaucoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.