Evidence map›Paper›PMID 30971808›Full record

ArticleThe pharmacogenomics journal2020

Identification of SAMD9L as a susceptibility locus for intravenous immunoglobulin resistance in Kawasaki disease by genome-wide association analysis.

Jae-Jung Kim, Sin Weon Yun, Jeong Jin Yu, Kyung Lim Yoon, Kyung-Yil Lee, Hong-Ryang Kil, Gi Beom Kim, Myung-Ki Han, Min Seob Song, Hyoung Doo Lee and 11 more

Open access · greenAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in The pharmacogenomics journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 15 institutions in 2 countries.

Jae-Jung KimAsan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea.
Sin Weon YunDepartment of Pediatrics, Chung-Ang University Hospital, Seoul, Korea.
Jeong Jin YuDepartment of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Kyung Lim YoonDepartment of Pediatrics, Kyung Hee University Hospital at Gangdong, Seoul, Korea.
Kyung-Yil LeeDepartment of Pediatrics, The Catholic University of Korea, Daejeon St. Mary's Hospital, Daejeon, Korea.
Hong-Ryang KilDepartment of Pediatrics, Chungnam National University Hospital, Daejeon, Korea.
Gi Beom KimDepartment of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.
Myung-Ki HanDepartment of Pediatrics, University of Ulsan, Gangneung Asan Hospital, Gangneung, Korea.
Min Seob SongDepartment of Pediatrics, Inje University Paik Hospital, Busan, Korea.
Hyoung Doo LeeDepartment of Pediatrics, Pusan National University Hospital, Busan, Korea.
Kee Soo HaDepartment of Pediatrics, Korea University Hospital, Seoul, Korea.
Sejung SohnDepartment of Pediatrics, Ewha Womans University Hospital, Seoul, Korea.
Ryota EbataDepartment of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan.
Hiromichi HamadaDepartment of Pediatrics, Tokyo Women's Medical University Yachiyo Medical Center, Chiba, Japan.
Hiroyuki SuzukiDepartment of Pediatrics, Wakayama Medical University, Wakayama, Japan.
Kaoru ItoLaboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Yoshihiro OnouchiLaboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Young Mi HongDepartment of Pediatrics, Ewha Womans University Hospital, Seoul, Korea.
Gi Young JangDepartment of Pediatrics, Korea University Hospital, Seoul, Korea.
Jong-Keuk LeeAsan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea. cookie_jklee@hotmail.com.ORCID http://orcid.org/0000-0003-1125-4017
and the Korean Kawasaki Disease Genetics Consortium
Ulsan College · KRChiba University · JPEwha Womans University · KRKorea University Medical Center · KRChung-Ang University Hospital · KRChungnam National University Hospital · KRInje University Busan Paik Hospital · KRKyung Hee University Hospital at Gangdong · KRPusan National University Hospital · KRRIKEN Center for Integrative Medical Sciences · JPSeoul National University Children's Hospital · KRThe Catholic University of Korea Daejeon St. Mary's Hospital · KRTokyo Women's Medical University · JPUniversity of Ulsan · KRWakayama Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kawasaki disease (KD) is a systemic vasculitis affecting infants and children; it manifests as fever and signs of mucocutaneous inflammation. Intravenous immunoglobulin (IVIG) treatment effectively attenuates the fever and systemic inflammation. However, 10-20% patients are unresponsive to IVIG. To identify genetic variants influencing IVIG non-response in KD, a genome-wide association study (GWAS) and a replication study were performed using a total of 148 IVIG non-responders and 845 IVIG-responders in a Korean population. rs28662 in the sterile alpha motif domain-containing protein 9-like (SAMD9L) locus showed the most significant result in the joint analysis of GWAS and replication samples (odds ratio (OR) = 3.47, P = 1.39 × 10

Indexed as

ChildDrug ResistanceFemaleGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansImmunoglobulins, IntravenousMaleMucocutaneous Lymph Node SyndromeTumor Suppressor ProteinsImmunoglobulins, IntravenousSAMD9L protein, humanTumor Suppressor Proteins

Identifiers

PMID30971808
OpenAlexW2937418138

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.