Evidence map›Paper›PMID 30971805›Full record

SynthesisHypertension research : official journal of the Japanese Society of Hypertension2019

Are the cardiovascular outcomes of participants with white-coat hypertension poor compared to those of participants with normotension? A systemic review and meta-analysis.

Takeshi Fujiwara, Chisa Matsumoto, Kei Asayama, Takayoshi Ohkubo, Satoshi Hoshide

Abstract readComparative StudyMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Hypertension research : official journal of the Japanese Society of Hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019).Hypertension research : official journal of the Japanese Society of Hypertension · 2019
    Guideline
  2. The Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025).Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  3. Article
  4. Article
  5. Improving measurement accuracy and feasibility to support long-term blood pressure management.Hypertension research : official journal of the Japanese Society of Hypertension · 2022
    Article
  6. White-coat and masked hypertension and coronary artery disease: are they related or not?Hypertension research : official journal of the Japanese Society of Hypertension · 2020
    Article
  7. Effects of white-coat, masked and sustained hypertension on coronary artery stenosis and cardiac arrhythmia.Hypertension research : official journal of the Japanese Society of Hypertension · 2020
    Observational
  8. Observational
  9. Article
  10. Resistant Hypertension Updated Guidelines.Current cardiology reports · 2019
    Review
  11. Complications of White-coat Hypertension Compared to a Normotensive and Hypertensive Population.Heart views : the official journal of the Gulf Heart Association
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Takeshi FujiwaraDivision of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan.
Chisa MatsumotoDepartment of Cardiology, Tokyo Medical University, Tokyo, Japan.
Kei AsayamaDepartment of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan.
Takayoshi OhkuboDepartment of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan.
Satoshi HoshideDivision of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan. hoshide@jichi.ac.jp.
Jichi Medical University · JPTeikyo University · JPTokyo Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prognostic value of white-coat hypertension (WCH) remains controversial. We undertook a quantitative literature review to assess the risk of cardiovascular outcomes in untreated participants with WCH compared to that in participants with normotension. We searched databases (PubMed, Cochrane Library and the Ichu-Shi Web Japanese database) for peer-reviewed articles published until December 23, 2017 reporting studies evaluating the risk of cardiovascular outcomes in participants with WCH compared to that in participants with normotension. WCH was defined by having hypertension according to the conventional office blood pressure (BP) and being in the normotensive range (definitions of hypertension and normotension differed according to studies) for out-of-office BP measured at home or in an ambulatory setting. In total, 11 studies were included in the meta-analysis, which assessed the composite outcomes of morbidity and mortality on cardiovascular, stroke, and cardiac diseases, all-cause mortality, and deterioration to sustained hypertension in 8 (n = 11971), 2 (n = 6252), 2 (n = 6252), 5 (n = 10611), and 3 (n = 1722) studies, respectively. The risks for cardiovascular outcome and deterioration to sustained hypertension were significantly higher in WCH participants, with relative risks (95% confidence intervals) of 1.33 (1.10-1.62) and 2.85 (2.32-3.49), respectively, than in participants with normotension. In contrast, no significant differences were observed in the risk for stroke, cardiac outcomes or all-cause mortality. Our study suggests the importance of accurate and appropriate evaluation of WCH by utilizing out-of-office BP monitoring and the necessity for careful long-term follow-up of participants with WCH.

Indexed as

Blood PressureCardiovascular DiseasesDisease ProgressionHumansPrognosisTreatment OutcomeWhite Coat HypertensionCardiovascular outcomeDeterioration to sustained hypertensionMeta-analysisOut-of-office blood pressureWhite-coat hypertension.

Identifiers

PMID30971805
OpenAlexW2938028859

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.