ArticleScientific reports2019
Telocytes constitute a widespread interstitial meshwork in the lamina propria and underlying striated muscle of human tongue.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Telocytes in skeletal muscle: Emerging players in homeostasis and repair/regeneration.Histology and histopathology · 2026Review
- Identification and localization of telocyte-like cells in human umbilical cord stroma.Scientific reports · 2025Article
- Detection of neuron specific enolase in the lip and ear pinna of goat (Capra hircus): an immunohistochemical study.BMC veterinary research · 2025Article
- Telocytes: history, origin, identification, structure, distribution, and functions.Histochemistry and cell biology · 2025Review
- Telocytes: current methods of research, challenges and future perspectives.Cell and tissue research · 2024Review
- The tongue of the red-eared slider (Trachemys scripta elegans): morphological characterization through gross, light, scanning electron, and immunofluorescence microscopic examination.BMC veterinary research · 2024Article
- Telocytes in inflammatory bowel diseases: contributions to pathology and therapeutic potentials.Frontiers in cell and developmental biology · 2024Review
- Stromal cell-derived factor 1 (SDF-1) increases the number of telocytes in ex vivo and in vitro assays.Histochemistry and cell biology · 2023Article
- Review
- Telocytes' Role in Modulating Gut Motility Function and Development: Medical Hypotheses and Literature Review.International journal of molecular sciences · 2022Review
- Morphologic evidence of telocytes in human thyroid stromal tissue.Journal of cellular and molecular medicine · 2022Article
- Myotendinous Junction: Exercise Protocols Can Positively Influence Their Development in Rats.Biomedicines · 2022Article
- Telocytes: An Emerging Component of Stem Cell Niche Microenvironment.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2021Review
- Scleroderma-like Impairment in the Network of Telocytes/CD34International journal of molecular sciences · 2021Article
- Cardiac Telocytes 16 Years on-What Have We Learned So Far, and How Close Are We to Routine Application of the Knowledge in Cardiovascular Regenerative Medicine?International journal of molecular sciences · 2021Review
- Identification of PDGFRα-positive interstitial cells in the distal segment of the murine vas deferens.Scientific reports · 2021Article
- CD34+ Stromal Cells/Telocytes as a Source of Cancer-Associated Fibroblasts (CAFs) in Invasive Lobular Carcinoma of the Breast.International journal of molecular sciences · 2021Article
- Telocytes contribute to aging-related modifications in the prostate.Scientific reports · 2020Article
- Fish telocytes and their relation to rodlet cells in ruby-red-fin shark (rainbow shark) Epalzeorhynchos frenatum (Teleostei: Cyprinidae).Scientific reports · 2020Article
- From Bench to Bedside in Tongue Muscle Cancer Invasion and Back again: Gross Anatomy, Microanatomy, Surgical Treatments and Basic Research.Life (Basel, Switzerland) · 2020Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telocytes have recently emerged as unique interstitial cells defined by their extremely long, thin and moniliform prolongations termed telopodes. Despite growing evidence that these cells consistently reside in the stromal compartment of various organs from human beings, studies dealing with telocytes in structures of the oral cavity are scarce. Hence, the present morphologic study was undertaken to explore for the first time the presence and specific localization of telocytes within tissues of the normal human tongue, a complex muscular organ whose main functions include taste, speech, and food manipulation in the oral cavity. Telocytes were initially identified by CD34 immunostaining and confirmed by CD34/PDGFRα double immunofluorescence and transmission electron microscopy. CD34+/PDGFRα+ telocytes were organized in interstitial meshworks either in the tongue lamina propria or in the underlying striated muscle. Lingual telocytes were immunonegative for CD31, c-kit and α-SMA. Telopodes were finely distributed throughout the stromal space and concentrated beneath the lingual epithelium and around CD31+ vessels, skeletal muscle bundles/fibers, and intramuscular nerves and ganglia. They also enveloped salivary gland units outside the α-SMA+ myoepithelial cells and delimited lymphoid aggregates. These findings establish telocytes as a previously overlooked interstitial cell population worth investigating further in the setting of human tongue pathophysiology.
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