ArticleScientific reports2019
High quality reference genomes for toxigenic and non-toxigenic Vibrio cholerae serogroup O139.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 23 citations in OpenAlex.
- Prevalence and diversity of enteric pathogens among cholera treatment centre patients with acute diarrhea in Uvira, Democratic Republic of Congo.BMC infectious diseases · 2020Trial
- Genomic Characteristics and Antibiotic Resistance Evolution of Vibrio cholerae O139 - Anhui Province, China, 2013-2024.China CDC weekly · 2025Article
- Allelic variations and gene cluster modularity act as nonlinear bottlenecks for cholera emergence.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
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- Pathways of exposure to Vibrio Cholerae in an urban informal settlement in Nairobi, Kenya.PLOS global public health · 2024Article
- Molecular characterization of Vibrio species isolated from dairy and water samples.Scientific reports · 2023Article
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- Role of Bacteriophages in the Evolution of Pathogenic Vibrios and Lessons for Phage Therapy.Advances in experimental medicine and biology · 2023Article
- Genomic Epidemiology of Vibrio cholerae O139, Zhejiang Province, China, 1994-2018.Emerging infectious diseases · 2022Article
- Vibrio cholerae O139 genomes provide a clue to why it may have failed to usher in the eighth cholera pandemic.Nature communications · 2022Article
- Vibrio cholerae O139 persists in Dhaka, Bangladesh since 1993.PLoS neglected tropical diseases · 2021Article
- Novel Indole-Based Hydrazones as Potent Inhibitors of the α-class Carbonic Anhydrase from Pathogenic BacteriumInternational journal of molecular sciences · 2020Article
- The type IV pilus protein PilU functions as a PilT-dependent retraction ATPase.PLoS genetics · 2019Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Toxigenic Vibrio cholerae of the O139 serogroup have been responsible for several large cholera epidemics in South Asia, and continue to be of clinical and historical significance today. This serogroup was initially feared to represent a new, emerging V. cholerae clone that would lead to an eighth cholera pandemic. However, these concerns were ultimately unfounded. The majority of clinically relevant V. cholerae O139 isolates are closely related to serogroup O1, biotype El Tor V. cholerae, and comprise a single sublineage of the seventh pandemic El Tor lineage. Although related, these V. cholerae serogroups differ in several fundamental ways, in terms of their O-antigen, capsulation phenotype, and the genomic islands found on their chromosomes. Here, we present four complete, high-quality genomes for V. cholerae O139, obtained using long-read sequencing. Three of these sequences are from toxigenic V. cholerae, and one is from a bacterium which, although classified serologically as V. cholerae O139, lacks the CTXφ bacteriophage and the ability to produce cholera toxin. We highlight fundamental genomic differences between these isolates, the V. cholerae O1 reference strain N16961, and the prototypical O139 strain MO10. These sequences are an important resource for the scientific community, and will improve greatly our ability to perform genomic analyses of non-O1 V. cholerae in the future. These genomes also offer new insights into the biology of a V. cholerae serogroup that, from a genomic perspective, is poorly understood.
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