ArticleNPJ schizophrenia2019
Altered gene expression in antipsychotic-induced weight gain.
Article in NPJ schizophrenia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Three-week effect of amisulpride, aripiprazole, and olanzapine on gene expression in peripheral blood in individuals with schizophrenia spectrum disorders.The international journal of neuropsychopharmacology · 2026Article
- Developing a Polygenic Risk Score for Weight Gain in People Treated for Psychosis-Application in a Real-World Setting.Human psychopharmacology · 2026Article
- Bibliometric Analysis of Antipsychotic-induced Metabolic Disorder from 2006 to 2021 Based on WoSCC Database.Current neuropharmacology · 2025Article
- Mechanism and treatments of antipsychotic-induced weight gain.International journal of obesity (2005) · 2023Review
- Patients with schizophrenia and bipolar disorder display a similar global gene expression signature in whole blood that reflects elevated proportion of immature neutrophil cells with association to lipid changes.Translational psychiatry · 2023Article
- Polygenic risk scores enhance prediction of body mass index increase in individuals with a first episode of psychosis.European psychiatry : the journal of the Association of European Psychiatrists · 2023Article
- Association between antipsychotic medication and clinically relevant weight change: meta-analysis.BJPsych open · 2023Review
- The Gender-Specific Association of DRD2 Polymorphism with Metabolic Syndrome in Patients with Schizophrenia.Genes · 2022Article
- Alterations in Immune-Related Defensin Alpha 4 (International journal of inflammation · 2022Review
- Conserved immunomodulatory transcriptional networks underlie antipsychotic-induced weight gain.Translational psychiatry · 2021Article
- Metabolomic profiles associated with a mouse model of antipsychotic-induced food intake and weight gain.Scientific reports · 2020Article
- Early-pregnancy transcriptome signatures of preeclampsia: from peripheral blood to placenta.Scientific reports · 2020Article
- Leptin and psychiatric illnesses: does leptin play a role in antipsychotic-induced weight gain?Lipids in health and disease · 2020Review
- Second-Generation Antipsychotics and Dysregulation of Glucose Metabolism: Beyond Weight Gain.Cells · 2019Review
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Authors and funding
3 authors.
Funding
Abstract
Antipsychotic drugs are one of the largest types of prescribed drugs. However, antipsychotic-induced weight gain (AIWG) is a major problem for the patients. AIWG increases cardiovascular and cerebrovascular morbidity and mortality, and reduces quality of life and drug compliance. To characterize changes in gene expression related to AIWG, we sequenced total messenger RNA from the blood samples of two groups of schizophrenia patients before and after 3 months of treatment with antipsychotics. The "weight gain" group was defined by an increase of body mass index (BMI) >1.5 points (18 patients; median BMI increase = 2.69) and the "no weight gain" group was defined by a change of BMI between <1.0 and >-1.0 points (18 patients; median BMI increase = 0.26). We found 115 genes with significant differential expression in the weight gain group before and after medication and 156 in the no weight gain group before and after medication. The weight gain group was significantly enriched with genes related to "obesity" and "BMI" (Fisher; p = 0.0002 and 0.01, respectively) according to the Gene Reference into Function (GeneRIF) database. In the no weight gain group, the enrichment was much smaller (Fisher; p = 0.02 and 0.79). This study is a first step toward detecting genetic factors that cause AIWG and to generating prediction tests in future studies with larger data sets.
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