Evidence map›Paper›PMID 30971494›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Regenerative therapy based on miRNA-302 mimics for enhancing host recovery from pneumonia caused by

Yan Wang, Yong Li, Peggy Zhang, Sandy T Baker, Marla R Wolfson, Jeffrey N Weiser, Ying Tian, Hao Shen

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. RNA therapeutics in the clinic.Bioengineering & translational medicine · 2023
    Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Alveolar Regeneration in COVID-19 Patients: A Network Perspective.International journal of molecular sciences · 2021
    Review
  16. Article
  17. miRNAs in Lung Development and Diseases.International journal of molecular sciences · 2020
    Review
  18. Article
  19. Observational
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Yan WangState Key Laboratory of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, 510230 Guangzhou, China.
Yong LiDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Peggy ZhangDepartment of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140.
Sandy T BakerDepartment of Physiology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140.
Marla R WolfsonDepartment of Physiology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140.
Jeffrey N WeiserDepartment of Microbiology, New York University School of Medicine, New York, NY 10016.
Ying TianDepartment of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140; ying.tian@temple.edu hshen@pennmedicine.upenn.edu.
Hao ShenDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; ying.tian@temple.edu hshen@pennmedicine.upenn.edu.ORCID 0000-0002-5003-4992
Temple Lung Center · USTemple University · USFirst Affiliated Hospital of Guangzhou Medical University · CNNew York University · USShanghai Jiao Tong University · CNUniversity of Pennsylvania · US

Funding

ROLE OF OPACITY VARIATION IN PNEUMOCOCCAL PATHOGENESISR01AI038446 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI WEISER, JEFFREY NEAL · 1996 to 2019
$7.4M
Development of a novel adjuvant for vaccine sparingR01AI105431 · NIAID · NEW YORK BLOOD CENTER · PI BOTTAZZI, MARIA ELENA, LUSTIGMAN, SARA · 2013 to 2017
$6.3M
Mechanisms of Pneumococcal Persistence During CarriageR37AI038446 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Jeffrey Neal Weiser · 2020 to 2026
$3.8M
Treating chronic viral infection by epigenetic reprogramming of exhausted CD8 T cellsR01AI130115 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ABT, MICHAEL C. · 2017 to 2021
$2.7M
Early Events in Pneumococcal ColonizationR01AI105168 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI WEISER, JEFFREY NEAL · 2014 to 2018
$2.1M
Regulation of distal lung epithelial regeneration by microRNA-Hippo pathwayR01HL132115 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI TIAN, YING · 2016 to 2020
$2.0M
Mechanisms of Haemophilus influenzae pathogenesis in the lungR01AI095740 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI AKERLEY, BRIAN, SHEN, HAO · 2012 to 2016
$1.8M
miRNAs regulate lung epithelial progenitor cells in development and injury repairR00HL111348 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI TIAN, YING · 2014 to 2016
$747k
Regenerative therapy for lung infection by S. pneumoniaeR21AI128569 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SHEN, HAO · 2017 to 2018
$456k
NHLBI NIH HHS R00 HL111348NHLBI NIH HHS R01 HL132115NIAID NIH HHS R01 AI038446NIAID NIH HHS R01 AI095740NIAID NIH HHS R01 AI105168NIAID NIH HHS R01 AI105431NIAID NIH HHS R01 AI130115NIAID NIH HHS R21 AI128569NIAID NIH HHS R37 AI038446
6 · The paper itself

Abstract

Bacterial pneumonia remains a leading cause of morbidity and mortality worldwide. A defining feature of pneumonia is lung injury, leading to protracted suffering and vulnerability long after bacterial clearance. Little is known about which cells are damaged during bacterial pneumonia and if the regenerative process can be harnessed to promote tissue repair and host recovery. Here, we show that infection of mice with

Indexed as

Alveolar Epithelial CellsAnimalsCell ProliferationDisease Models, AnimalLungMiceMice, Inbred C57BLMicroRNAsPneumonia, PneumococcalRegenerationRNA, Double-StrandedStreptococcus pneumoniaeMicroRNAsRNA, Double-StrandedalveolusbacteriamiRNApneumoniaregeneration

Identifiers

PMID30971494
PMCPMC6486708
OpenAlexW2939554096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.