Evidence map›Paper›PMID 30971493›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Jun Ohshima, Qian Wang, Zackary R Fitzsimonds, Daniel P Miller, Maryta N Sztukowska, Young-Jung Jung, Mikako Hayashi, Marvin Whiteley, Richard J Lamont

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. The Role ofCancers · 2025
    Review
  4. Article
  5. Review
  6. Review
  7. Frontiers in cellular and infection microbiology · 2025
    Review
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  9. Article
  10. Review
  11. Review
  12. Article
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Jun OhshimaDepartment of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY 40202.
Qian WangDepartment of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY 40202.
Zackary R FitzsimondsDepartment of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY 40202.
Daniel P MillerDepartment of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY 40202.
Maryta N SztukowskaDepartment of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY 40202.
Young-Jung JungDepartment of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY 40202.
Mikako HayashiDepartment of Restorative Dentistry and Endodontology, Graduate School of Dentistry, Osaka University, 565-0871 Osaka, Japan.
Marvin WhiteleySchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332.
Richard J LamontDepartment of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY 40202; rich.lamont@louisville.edu.ORCID 0000-0002-3147-5039
University of Louisville · USGeorgia Institute of Technology · USThe University of Osaka · JP

Funding

MOLECULAR ASPECTS OF ORAL PLAQUE FORMATIONR01DE012505 · NIDCR · UNIVERSITY OF WASHINGTON · PI Richard J Lamont, JAN S POTEMPA · 1998 to 2026
$9.5M
P GINGIVALIS INTERACTIONS WITH GINGIVAL EPITHELIAL CELLSR01DE011111 · NIDCR · UNIVERSITY OF WASHINGTON · PI HARIBABU BODDULURI, Richard J Lamont · 1995 to 2026
$5.4M
Probing Polymicrobial Synergy Using hihg Throughout GenomicsR01DE023193 · NIDCR · UNIVERSITY OF TEXAS AT AUSTIN · PI LAMONT, RICHARD J, WHITELEY, MARVIN · 2013 to 2023
$4.7M
P.gingivalis Interactions with Gingival Epithelial CellsR37DE011111 · NIDCR · UNIVERSITY OF LOUISVILLE · PI LAMONT, RICHARD J · 2009 to 2018
$3.6M
Role of JAKs in innate responses to P. gingivalisR01DE017921 · NIDCR · UNIVERSITY OF LOUISVILLE · PI LAMONT, RICHARD J · 2010 to 2019
$3.3M
Polymicrobial Synergy between Treponema denticola and Porphyromonas gingivalisR00DE028346 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI MILLER, DANIEL PATRICK · 2020 to 2022
$747k
Polymicrobial Synergy between Treponema denticola and Porphyromonas gingivalisK99DE028346 · NIDCR · UNIVERSITY OF LOUISVILLE · PI MILLER, DANIEL PATRICK · 2018 to 2019
$214k
Regulation of ZEB1 by Porphyromonas gingivalis in gingival epithelial cellsF30DE028166 · NIDCR · UNIVERSITY OF LOUISVILLE · PI FITZSIMONDS, ZACKARY R · 2018 to 2021
$150k
Phosphotyrosine Signaling of Porphyromonas gingivalisF32DE026939 · NIDCR · UNIVERSITY OF LOUISVILLE · PI MILLER, DANIEL PATRICK · 2017 to 2018
$96k
NIDCR NIH HHS F30 DE028166NIDCR NIH HHS F32 DE026939NIDCR NIH HHS K99 DE028346NIDCR NIH HHS R00 DE028346NIDCR NIH HHS R01 DE011111NIDCR NIH HHS R01 DE012505NIDCR NIH HHS R01 DE017921NIDCR NIH HHS R01 DE023193NIDCR NIH HHS R37 DE011111
6 · The paper itself

Abstract

The polymicrobial microbiome of the oral cavity is a direct precursor of periodontal diseases, and changes in microhabitat or shifts in microbial composition may also be linked to oral squamous cell carcinoma. Dysbiotic oral epithelial responses provoked by individual organisms, and which underlie these diseases, are widely studied. However, organisms may influence community partner species through manipulation of epithelial cell responses, an aspect of the host microbiome interaction that is poorly understood. We report here that

Indexed as

Epithelial Cellsbeta CateninCells, CulturedEpithelial-Mesenchymal TransitionForkhead Box Protein O1Host-Pathogen InteractionsHumansPorphyromonas gingivalisStreptococcus gordoniiZinc Finger E-box Binding Homeobox 2beta CateninCTNNB1 protein, humanForkhead Box Protein O1FOXO1 protein, humanZEB2 protein, humanZinc Finger E-box Binding Homeobox 2commensalEMTFOXO1periodontalpolymicrobial community

Identifiers

PMID30971493
PMCPMC6486779
OpenAlexW2936554272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.