ArticleProceedings of the National Academy of Sciences of the United States of America2019
Structural basis for auxiliary subunit KCTD16 regulation of the GABA
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
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Who cites it
37 citing papers in PubMed, 66 citations in OpenAlex.
- Shared Genetic Architecture of Premenstrual Disorder and Postpartum Depression: Registry-Based and Genetic Evidence.Research square · 2026Article
- NAcLat-DBS reduces GABANeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Blocking β-alanine synthesis triggers widespread perturbations of energy and lipid metabolism in the brain.Molecular metabolism · 2026Article
- A Global Analysis of the Complex Structural Organization of KCTD Proteins and Their Functional Implications.International journal of molecular sciences · 2026Review
- Chromatin Profiling Reveals Distinct Male and Female Trajectories for Developmental Learning Potential.Developmental neurobiology · 2026Article
- KCTD Family: Emerging Regulators of GPCR Biased Signaling.Handbook of experimental pharmacology · 2026Review
- Prioritizing long COVID related single nucleotide polymorphisms by mining genome-wide association studies of COVID-19 susceptibility and hospitalization.Frontiers in systems biology · 2026Article
- Smooth operator(s): dialing up and down neurotransmitter responses by G-protein regulators.Trends in cell biology · 2025Review
- Effects of moderate static magnetic fields on voltage-gated potassium ion channels in sympathetic neuron-like PC12 cells.Physiological reports · 2025Article
- Identification and study of mood-related biomarkers and potential molecular mechanisms in type 2 diabetes mellitus.Journal of molecular histology · 2025Article
- Receptor-dependent influence of R7 RGS proteins on neuronal GIRK channel signaling dynamics.Progress in neurobiology · 2024Article
- A BTB extension and ion-binding domain contribute to the pentameric structure and TFAP2A binding of KCTD1.Structure (London, England : 1993) · 2024Article
- Synaptotagmin-11 facilitates assembly of a presynaptic signaling complex in post-Golgi cargo vesicles.EMBO reports · 2024Article
- BTB domain mutations perturbing KCTD15 oligomerisation cause a distinctive frontonasal dysplasia syndrome.Journal of medical genetics · 2024Article
- A Comprehensive Analysis of the Structural Recognition between KCTD Proteins and Cullin 3.International journal of molecular sciences · 2024Article
- A Molecular Signature of the Ubiquitin-Proteasome System for Forecasting Prognosis in Thyroid Carcinoma Patients.Journal of inflammation research · 2024Article
- KCTD5 Forms Hetero-Oligomeric Complexes with Various Members of the KCTD Protein Family.International journal of molecular sciences · 2023Article
- Structural basis for the ubiquitination of G protein βγ subunits by KCTD5/Cullin3 E3 ligase.Science advances · 2023Article
- Article
- Sex differences in the transcriptome of extracellular vesicles secreted by fetal neural stem cells and effects of chronic alcohol exposure.Biology of sex differences · 2023Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 2 countries.
Hao ZuoDepartment of Pharmacology, Columbia University, New York, NY 10032.ORCID 0000-0002-8812-7385
Ian GlaaserDepartment of Pharmacology, Columbia University, New York, NY 10032.
Yulin ZhaoNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Igor KurinovDepartment of Chemistry & Chemical Biology, Cornell University, Ithaca, NY 14853.
Lidia MosyakDepartment of Pharmacology, Columbia University, New York, NY 10032.
Haonan WangKey Laboratory of Receptor Research, Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Jonathan LiuDepartment of Pharmacology, Columbia University, New York, NY 10032.
Jinseo ParkDepartment of Pharmacology, Columbia University, New York, NY 10032.
Aurel FrangajDepartment of Pharmacology, Columbia University, New York, NY 10032.
Emmanuel SturchlerDepartment of Molecular Therapeutics, The Scripps Translational Science Institute, Jupiter, FL 33458.
Ming ZhouVerma and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030.
Patricia McDonaldDepartment of Molecular Therapeutics, The Scripps Translational Science Institute, Jupiter, FL 33458.
Yong GengDepartment of Pharmacology, Columbia University, New York, NY 10032; gengyong@simm.ac.cn paul.slesinger@mssm.edu qf13@cumc.columbia.edu.
Paul A SlesingerNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029; gengyong@simm.ac.cn paul.slesinger@mssm.edu qf13@cumc.columbia.edu.ORCID 0000-0002-3868-7528
Qing R FanDepartment of Pharmacology, Columbia University, New York, NY 10032; gengyong@simm.ac.cn paul.slesinger@mssm.edu qf13@cumc.columbia.edu.ORCID 0000-0002-9330-0963
Columbia University · USAllen Institute for Brain Science · USChinese Academy of Sciences · CNScripps Research Institute · USBaylor College of Medicine · USCornell University · US
Funding
User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2MOverall EvaluationP41GM103403 · NIGMS · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2012 to 2017
$14.3MStructural Analysis of Alcohol-dependent Activation of GIRKsR01AA018734 · NIAAA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Paul A Slesinger · 2010 to 2026
$6.6MDissecting Mechanisms of GABAB-GIRK Plasticity with PsychostimulantsR01DA037170 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MOSS, STEPHEN J, SLESINGER, PAUL A · 2014 to 2018
$2.1MPixel Array Detector for X-ray CrystallographyS10RR029205 · NCRR · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2010 to 2010
$1.8MMechanism of activation and modulation in human GABA(B) receptorR01GM125801 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FAN, QING R, QUICK, MATTHIAS · 2018 to 2021
$1.7MStructural Studies of Metabotropic GABA ReceptorsR01GM088454 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FAN, QING R · 2009 to 2015
$1.6MNCRR NIH HHS S10 RR029205NIAAA NIH HHS R01 AA018734NIDA NIH HHS R01 DA037170NIGMS NIH HHS P30 GM124165NIGMS NIH HHS P41 GM103403NIGMS NIH HHS R01 GM088454NIGMS NIH HHS R01 GM125801
Abstract
Metabotropic GABA
Indexed as
Intracellular Signaling Peptides and ProteinsNerve Tissue ProteinsReceptors, GABA-BBinding SitesCrystallographyHumansModels, MolecularProtein BindingSignal TransductionIntracellular Signaling Peptides and ProteinsKCTD16 protein, humanNerve Tissue ProteinsReceptors, GABA-Bcrystal structureGABAB receptorKCTDprincipal and auxiliary subunits
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.