ArticleProceedings of the National Academy of Sciences of the United States of America2019
Locus coeruleus toggles reciprocal prefrontal firing to reinstate fear.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Who cites it
29 citing papers in PubMed.
- Review
- A locus coeruleus-centric framework for novelty, salience, and gamma oscillations: implications for neurostimulation, aging, and disease.Frontiers in aging neuroscience · 2026Article
- Stress reactivity is modulated by cannabinoid type-1 receptors in norepinephrine and epinephrine neurons in a context-dependent manner.Neuroscience · 2025Article
- Experience-dependent maternal defense behavior mediated by profrontal cortical projections to the medial preoptic area in mice.Nature communications · 2025Article
- Bidirectional emotional regulation through prefrontal innervation of the locus coeruleus.Molecular psychiatry · 2025Article
- Functional and Regional Specificity of Noradrenergic Signaling for Encoding and Retrieval of Associative Recognition Memory in the Rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Alpha-2 agonism in the locus coeruleus impairs learning driven by negative prediction error.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Optogenetic inhibition of the locus coeruleus blocks vagus nerve stimulation-induced enhancement of extinction of conditioned fear in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Stimulation of Locus Ceruleus Inputs to the Prelimbic Cortex in Mice Induces Cell Type-Specific Expression of theeNeuro · 2024Article
- Hippocampal contextualization of social rewards in mice.Nature communications · 2024Article
- Article
- Neural circuits for the adaptive regulation of fear and extinction memory.Frontiers in behavioral neuroscience · 2024Review
- Parvalbumin-Positive Interneurons in the Medial Prefrontal Cortex Regulate Stress-Induced Fear Extinction Impairments in Male and Female Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Temporal model for central sensitization: A hypothesis for mechanism and treatment using systemic manual therapy, a focused review.MethodsX · 2023Review
- Hippocampus and amygdala fear memory engrams re-emerge after contextual fear relapse.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Feasibility of Canine Adenovirus Type 2 (CAV2) Based Vector for the Locus Coeruleus Optogenetic Activation in Non-Transgenic Rats: Implications for Functional Studies.Brain sciences · 2022Article
- Convergent Coding of Recent and Remote Fear Memory in the Basolateral Amygdala.Biological psychiatry · 2022Article
- Unrelenting Fear Under Stress: Neural Circuits and Mechanisms for the Immediate Extinction Deficit.Frontiers in systems neuroscience · 2022Review
- Noradrenergic Signaling Disengages Feedforward Transmission in the Nucleus Accumbens Shell.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Contributions of glucocorticoid receptors in cortical astrocytes to memory recall.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
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Authors and funding
4 authors.
Funding
Abstract
The medial prefrontal cortex (mPFC) plays an essential role in regulating emotion, including inhibiting fear when danger has passed. The extinction of fear, however, is labile and a number of factors, including stress, cause extinguished fear to relapse. Here we show that fear relapse in rats limits single-unit activity among infralimbic (IL) neurons, which are critical for inhibiting fear responses, and facilitates activity in prelimbic (PL) neurons involved in fear expression. Pharmacogenetic activation of noradrenergic neurons in the locus coeruleus mimics this shift in reciprocal IL-PL spike firing, increases the expression of conditioned freezing behavior, and causes relapse of extinguished fear. Noradrenergic modulation of mPFC firing represents a mechanism for relapse and a potential target for therapeutic interventions to reduce pathological fear.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.