ArticleNeurology2019
Lipid levels and the risk of hemorrhagic stroke among women.
Article in Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06229834 (Chiropractic Care for Episodic Migraine), which is not on this map. Cited by 74 papers, 7 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Chiropractic Care for Episodic Migraine
Who cites it
74 citing papers in PubMed, 7 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Relationship between serum lipids and the risk of hemorrhagic stroke: a meta-analysis of 50 million participants from prospective cohort studies.Lipids in health and disease · 2025Pooled it
- Low-Density Lipoprotein Cholesterol Reductions of not Less Than 60 mg/dL Prevent Hemorrhagic Stroke in Hypertensive Populations: A Meta-analysis.Reviews in cardiovascular medicine · 2025Pooled it
- Risk Factors of Aneurysmal Subarachnoid Hemorrhage Including Analysis by Sex: A Systematic Review and Meta-Analysis.Neurology · 2025Pooled it
- A global analysis of dairy consumption and incident cardiovascular disease.Nature communications · 2025Pooled it
- Pooled it
- Dose-Response Association Between High-Density Lipoprotein Cholesterol and Stroke: A Systematic Review and Meta-Analysis of Prospective Cohort Studies.Preventing chronic disease · 2021Pooled it
- Low-Density Lipoprotein Cholesterol and Risk of Hemorrhagic Stroke: a Systematic Review and Dose-Response Meta-analysis of Prospective Studies.Current atherosclerosis reports · 2019Pooled it
- The risk of ischemic stroke and hemorrhagic stroke in Chinese adults with low-density lipoprotein cholesterol concentrations < 70 mg/dL.BMC medicine · 2021Trial
- Trial
- Effect of Alirocumab on Stroke in ODYSSEY OUTCOMES.Circulation · 2019Trial
- Low levels of low-density lipoprotein cholesterol in older adults are inversely associated with the incidence of coronary artery disease and all-cause mortality: the Shizuoka Kokuho Database study.European geriatric medicine · 2026Article
- Association of long-term exposure to lower low-density lipoprotein cholesterol with neuroimaging metrics: A population-based cohort study.Chinese medical journal · 2026Observational
- Dual clinical utility of cholesterol, high density lipoprotein, and glucose index: from advanced cardiovascular-kidney-metabolic syndrome pathogenesis to inflammatory-mediated mortality across early-transitional stages.Diabetology & metabolic syndrome · 2025Article
- Review
- Low apolipoprotein B and LDL-cholesterol are associated with the risk of cardiovascular and all-cause mortality: a prospective cohort.Annals of medicine · 2025Article
- Pushing the limits of LDL cholesterol: Emerging paradigms in cardiovascular risk reduction.Trends in cardiovascular medicine · 2025Review
- The association between triglyceride glucose-body mass index and all-cause mortality in critically ill patients undergoing cardiac surgery: a retrospective analysis from the MIMIC-IV database.BMC cardiovascular disorders · 2025Article
- Chronic integrated stress response causes dysregulated cholesterol synthesis in white matter disease.JCI insight · 2025Article
- Low Cholesterol Concentrations and the Risk of Peptic Ulcer Bleeding: A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Emerging risks of lipid-lowering therapy and low LDL levels: implications for eye, brain, and new-onset diabetes.Lipids in health and disease · 2025Article
14 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo examine the association between lipid levels and hemorrhagic stroke risk among women.
methodsWe performed a prospective cohort study among 27,937 women enrolled in the Women's Health Study with measured total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), as well as triglycerides. Strokes were confirmed by medical record review. We used Cox proportional hazards models to analyze associations between lipid categories and hemorrhagic stroke risk.
resultsDuring a mean of 19.3 years of follow-up, 137 hemorrhagic strokes occurred. Compared to those with LDL-C levels 100-129.9 mg/dL, after multivariable adjustment, those with LDL-C levels <70 mg/dL had 2.17 times the risk (95% confidence interval [CI] 1.05, 4.48) of experiencing a hemorrhagic stroke. No significant increase in risk was seen for those with LDL-C levels 130-159.9 mg/dL (relative risk [RR] 1.14; 95% CI 0.72, 1.80) or 70-99.9 mg/dL (RR 1.25; 95% CI 0.76, 2.04). There was a suggestion, although not significant, of increased risk for those with LDL-C levels ≥160 mg/dL (RR 1.53; 95% CI 0.92, 2.52). Women in the lowest quartile of triglycerides had a significantly increased risk of hemorrhagic stroke compared to women in the top quartile after multivariable adjustment (RR 2.00; 95% CI 1.18, 3.39). We observed no significant associations between total cholesterol or HDL-C levels and hemorrhagic stroke risk.
conclusionLDL-C levels <70 mg/dL and low triglyceride levels were associated with increased risk of hemorrhagic stroke among women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.