Evidence map›Paper›PMID 30971475›Full record

ArticleJournal of virology2019

Andrew K Hastings, Ryuta Uraki, Hallie Gaitsch, Khushwant Dhaliwal, Sydney Stanley, Hannah Sproch, Eric Williamson, Tyler MacNeil, Alejandro Marin-Lopez, Jesse Hwang and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 67 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Contribution of Immune Responses toJournal of inflammation research · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Virulence · 2025
    Article
  9. Article
  10. A single-nucleus transcriptomic atlas of the adultbioRxiv : the preprint server for biology · 2025
    Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Immunosuppressive impact ofFrontiers in immunology · 2025
    Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Andrew K HastingsSection of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Ryuta UrakiSection of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Hallie GaitschSection of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Khushwant DhaliwalSection of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Sydney StanleySection of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Hannah SprochSection of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Eric WilliamsonSection of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Tyler MacNeilSection of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Alejandro Marin-LopezSection of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Jesse HwangSection of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Yuchen WangSection of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Jonathan R GroverSection of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Erol FikrigSection of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA erol.fikrig@yale.edu.
Yale University · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Howard Hughes Medical InstituteNCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA016086
6 · The paper itself

Abstract

Saliva from the mosquito vector of flaviviruses is capable of changing the local immune environment, leading to an increase in flavivirus-susceptible cells at the infected bite site. In addition, an antibody response to specific salivary gland (SG) components changes the pathogenesis of flaviviruses in human populations. To investigate whether antigenic SG proteins are capable of enhancing infection with Zika virus (ZIKV), a reemerging flavivirus primarily transmitted by the

Indexed as

AedesAnimalsArbovirusesChemokine CCL2Chemokine CXCL2Disease Models, AnimalFemaleImmunityInterleukin-1MaleMiceMice, Inbred C57BLMosquito VectorsNeutrophilsProtein PrecursorsRAW 264.7 CellsCcl2 protein, mouseChemokine CCL2Chemokine CXCL2Cxcl2 protein, mouseInterleukin-1interleukin 1 precursorProtein Precursorsarthropod-borne virusflavivirusimmunitymosquitomosquito-borneneutrophilssalivary glandvaccineviral pathogenesisZika virus

Identifiers

PMID30971475
PMCPMC6580965
OpenAlexW2937798725

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.