Evidence map›Paper›PMID 30971458›Full record

ReviewThe Biochemical journal2019

lncRedibly versatile: biochemical and biological functions of long noncoding RNAs.

Emily J Shields, Ana F Petracovici, Roberto Bonasio

Open access · greenAbstract readReview
In one paragraph

Review in The Biochemical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Circulating miRNAs and Preeclampsia: From Implantation to Epigenetics.International journal of molecular sciences · 2024
    Review
  8. Article
  9. Male-specific roles of lincRNA inFrontiers in cell and developmental biology · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. microPublication biology · 2022
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Functional Intricacy and Symmetry of Long Non-Coding RNAs in Parasitic Infections.Frontiers in cellular and infection microbiology · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Emily J ShieldsEpigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, U.S.A.
Ana F PetracoviciEpigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, U.S.A.
Roberto BonasioEpigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, U.S.A. roberto@bonasiolab.org.ORCID 0000-0002-0767-0889
University of Pennsylvania · US

Funding

Training Program in Computational GenomicsT32HG000046 · NHGRI · UNIVERSITY OF PENNSYLVANIA · PI JUNHYONG KIM, Mingyao Li · 1999 to 2026
$9.5M
Graduate Training in Developmental BiologyT32HD083185 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI Michael Granato, Foteini Mourkioti · 2015 to 2026
$4.0M
Studying epigenetic pathways in brain function and social behavior using antsDP2MH107055 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BONASIO, ROBERTO · 2014 to 2014
$2.4M
Function and RNA-mediated regulation of SCMH1 in Polycomb repressionR01GM127408 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BONASIO, ROBERTO · 2018 to 2021
$1.3M
NHGRI NIH HHS T32 HG000046NICHD NIH HHS T32 HD083185NIGMS NIH HHS R01 GM127408NIMH NIH HHS DP2 MH107055
6 · The paper itself

Abstract

Long noncoding RNAs (lncRNAs) are transcripts that do not code for proteins, but nevertheless exert regulatory effects on various biochemical pathways, in part via interactions with proteins, DNA, and other RNAs. LncRNAs are thought to regulate transcription and other biological processes by acting, for example, as guides that target proteins to chromatin, scaffolds that facilitate protein-protein interactions and complex formation, and orchestrators of phase-separated compartments. The study of lncRNAs has reached an exciting time, as recent advances in experimental and computational methods allow for genome-wide interrogation of biochemical and biological mechanisms of these enigmatic transcripts. A better appreciation for the biochemical versatility of lncRNAs has allowed us to begin closing gaps in our knowledge of how they act in diverse cellular and organismal contexts, including development and disease.

Indexed as

AnimalsBiochemical PhenomenaChromatinDNAHumansModels, BiologicalProtein BindingRNA, Guide, CRISPR-Cas SystemsRNA, Long NoncodingChromatinDNARNA, Guide, CRISPR-Cas SystemsRNA, Long Noncodingchromatinepigeneticsgene expression and regulationlarge intervening noncoding RNARNA-binding proteins

Identifiers

PMID30971458
PMCPMC6745715
OpenAlexW2936347774

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.