Evidence map›Paper›PMID 30971455›Full record

ArticleScience translational medicine2019

Impact of antibiotic treatment and host innate immune pressure on enterococcal adaptation in the human bloodstream.

Daria Van Tyne, Abigail L Manson, Mark M Huycke, John Karanicolas, Ashlee M Earl, Michael S Gilmore

Abstract read
In one paragraph

Article in Science translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 53 citations in OpenAlex.

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  11. The Impact ofPathogens (Basel, Switzerland) · 2024
    Review
  12. Article
  13. Article
  14. Article
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  16. Article
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  18. Article
  19. Genome and transcriptome analysis ofFrontiers in microbiology · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Daria Van TyneDepartment of Ophthalmology and Department of Microbiology, Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0001-7284-0103
Abigail L MansonInfectious Disease and Microbiome Program, Broad Institute, Cambridge, MA 02142, USA.ORCID 0000-0002-3800-0714
Mark M HuyckeDepartment of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.ORCID 0000-0002-6110-5629
John KaranicolasProgram in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.ORCID 0000-0003-0300-726X
Ashlee M EarlInfectious Disease and Microbiome Program, Broad Institute, Cambridge, MA 02142, USA.ORCID 0000-0001-7857-9145
Michael S GilmoreDepartment of Ophthalmology and Department of Microbiology, Harvard Medical School, Boston, MA 02114, USA. michael_gilmore@meei.harvard.edu.ORCID 0000-0001-6389-832X
Broad Institute · USFox Chase Cancer Center · USUniversity of Oklahoma Health Sciences Center · US

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Margaret von Mehren · 1985 to 2026
$138.8M
Viral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI NEAFSEY, DANIEL E · 2014 to 2024
$66.5M
Technical Mother Machine CoreP01AI083214 · NIAID · SCHEPENS EYE RESEARCH INSTITUTE · PI Michael S Gilmore · 2009 to 2026
$39.4M
E. faecalis Pathogenicity IslandR01AI072360 · NIAID · SCHEPENS EYE RESEARCH INSTITUTE · PI GILMORE, MICHAEL S · 2007 to 2017
$3.8M
Bacterial Evasion of Innate Defenses at the Ocular SurfaceR00EY028222 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VAN TYNE, DARIA N · 2018 to 2020
$728k
Bacterial Evasion of Innate Defenses at the Ocular SurfaceK99EY028222 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI VAN TYNE, DARIA N · 2017 to 2017
$95k
NCI NIH HHS P30 CA006927NEI NIH HHS K99 EY028222NEI NIH HHS R00 EY028222NIAID NIH HHS HHSN272200900018CNIAID NIH HHS P01 AI083214NIAID NIH HHS R01 AI072360NIAID NIH HHS U19 AI110818
6 · The paper itself

Abstract

Multidrug-resistant enterococcal strains emerged in the early 1980s and are now among the leading causes of drug-resistant bacterial infection worldwide. We used functional genomics to study an early bacterial outbreak in patients in a Wisconsin hospital between 1984 and 1988 that was caused by multidrug-resistant

Indexed as

Adaptation, PhysiologicalAnti-Bacterial AgentsCarbapenemsDisease OutbreaksDrug Resistance, MicrobialEnterococcus faeciumGenetic LociGenetic VariationGenome, BacterialGram-Positive Bacterial InfectionsHospitalsHost-Pathogen InteractionsHumansImmunity, InnateLipopolysaccharidesMutationAnti-Bacterial AgentsCarbapenemsLipopolysaccharideslipoteichoic acidN-Glycosyl HydrolasesTeichoic Acids

Identifiers

PMID30971455
PMCPMC6681809
OpenAlexW2937008344

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.