Evidence map›Paper›PMID 30971430›Full record

ArticleThe Journal of biological chemistry2019

The complement receptor C5aR2 promotes protein kinase R expression and contributes to NLRP3 inflammasome activation and HMGB1 release from macrophages.

Songlin Yu, Dan Wang, Lingmin Huang, Yening Zhang, Ruiheng Luo, Dickson Adah, Yiting Tang, Kai Zhao, Ben Lu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 68 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Disseminated intravascular coagulation.Journal of intensive care · 2025
    Review
  5. Article
  6. Involvement of role of HMGB1-NLRP3 pathway in systemic disorders.Frontiers in cell and developmental biology · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Human Resistin Induces Cardiac Dysfunction in Pulmonary Hypertension.Journal of the American Heart Association · 2023
    Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. An integrated analysis ofCancer innovation · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Songlin YuDepartment of Hematology and Key Laboratory of Non-resolving Inflammation and Cancer of Hunan Province, Third Xiangya Hospital, Central South University, Changsha, Hunan 410000, China; Postdoctoral Research Station of Clinical Medicine, Third Xiangya Hospital, Central South University, Changsha, Hunan 410000, China.
Dan WangDepartment of Hematology and Key Laboratory of Non-resolving Inflammation and Cancer of Hunan Province, Third Xiangya Hospital, Central South University, Changsha, Hunan 410000, China.
Lingmin HuangDepartment of Hematology and Key Laboratory of Non-resolving Inflammation and Cancer of Hunan Province, Third Xiangya Hospital, Central South University, Changsha, Hunan 410000, China.
Yening ZhangDepartment of Hematology and Key Laboratory of Non-resolving Inflammation and Cancer of Hunan Province, Third Xiangya Hospital, Central South University, Changsha, Hunan 410000, China.
Ruiheng LuoDepartment of Hematology and Key Laboratory of Non-resolving Inflammation and Cancer of Hunan Province, Third Xiangya Hospital, Central South University, Changsha, Hunan 410000, China.
Dickson AdahLaboratory of Pathogen Biology, State Key Laboratory of Respiratory Disease, Center for Infection and Immunity, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510632, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Yiting TangDepartment of Physiology, School of Basic Medical Science, Central South University, Changsha, Hunan 410000, China.
Kai ZhaoDepartment of Hematology and Key Laboratory of Non-resolving Inflammation and Cancer of Hunan Province, Third Xiangya Hospital, Central South University, Changsha, Hunan 410000, China. Electronic address: kaizhao@csu.edu.cn.
Ben LuDepartment of Hematology and Key Laboratory of Non-resolving Inflammation and Cancer of Hunan Province, Third Xiangya Hospital, Central South University, Changsha, Hunan 410000, China; Key Laboratory of Medical Genetics, School of Biological Science and Technology, Central South University, Changsha, Hunan 410000, China; Key Laboratory of Sepsis and Translational Medicine, School of Basic Medical Science, Central South University, Changsha, Hunan 410000, China; Department of Pathophysiology, School of Basic Medical Science, Jinan University, Guangzhou, Guangdong 510632, China. Electronic address: xybenlu@csu.edu.cn.
Third Xiangya Hospital · CNCentral South University · CNGuangzhou Institutes of Biomedicine and Health · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The NLR family pyrin domain-containing 3 (NLRP3) inflammasome is a multimeric protein complex that mediates maturation of the cytokines IL-1β and IL-18 as well as release of the proinflammatory protein high-mobility group box 1 (HMGB1) and contributes to several inflammatory diseases, including sepsis, gout, and type 2 diabetes. In this context, the well-studied active complement fragment C5a and its receptor C5aR1 or C5aR2 orchestrate the inflammatory responses in many diseases. Although a C5a-C5aR interaction in NLRP3-associated diseases has been suggested, little is known about the details of C5a-C5aR cross-talk with the NLRP3 inflammasome in macrophages. In this study, using mice and murine macrophages and cytokines, immunoblotting, siRNA, and quantitative real-time PCR assays, we demonstrate that C5aR2 deficiency restricts activation of the NLRP3 inflammasome and release of HMGB1 both

Indexed as

Gene Expression Regulation, EnzymologicAnimalsComplement C5aeIF-2 KinaseHMGB1 ProteinInflammasomesMacrophagesMiceMice, KnockoutNLR Family, Pyrin Domain-Containing 3 ProteinReceptor, Anaphylatoxin C5aC5ar2 protein, mouseComplement C5aeIF-2 KinaseHMGB1 ProteinHMGB1 protein, mouseInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseprotein kinase R, mouseReceptor, Anaphylatoxin C5acomplement systemIL-1immunologyinflammasomeinflammation

Identifiers

PMID30971430
PMCPMC6544858
OpenAlexW2939877466

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.