ArticleThe Journal of biological chemistry2019
Enhancer of zeste homolog 2 (EZH2) regulates adipocyte lipid metabolism independent of adipogenic differentiation: Role of apolipoprotein E.
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Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
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Who cites it
30 citing papers in PubMed, 38 citations in OpenAlex.
- An EZH2-SREBP2 axis promotes cholesterol biosynthesis and represents a noncanonical vulnerability in tumorigenesis.Nature cell biology · 2026Article
- Histone Modifications: Decoding the Epigenetic Basis of Economic Traits in Livestock and Poultry.Genes · 2026Review
- Histone Deacetylase 9 Gene Deletion Ameliorates Aging-Related Adipose Tissue Senescence and Mitochondrial Dysfunction in Mice.Aging cell · 2026Article
- Cadmium Toxicity Effects on Histone Modifiers, Enzyme Activity and Adipokines in Human Adipose Tissue Cells.Molecules (Basel, Switzerland) · 2026Article
- Epigenomic and Metabolic Interplay in the Development of Metastatic Brain Tumors.Oncology research · 2026Review
- Multiomics strategy-based obesity biomarkers discovery for precision medicine.International journal of obesity (2005) · 2026Review
- Emerging Roles of Post-Translational Modifications in Metabolic Homeostasis and Type 2 Diabetes.International journal of molecular sciences · 2025Review
- Genetic insights of waist-to-height ratio on the risk of steatotic and advanced liver diseases: genome-wide association study and polygenic risk score-based analyses.Human genomics · 2025Article
- Epigenetic Changes Associated With Obesity-related Metabolic Comorbidities.Journal of the Endocrine Society · 2025Review
- Article
- Enhancer zeste homolog 2 (EZH2) targeting by small interfering RNA (siRNA); recent advances and prospect.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- A targetable antioxidant defense mechanism to EZH2 inhibitors enhances tumor cell vulnerability to ferroptosis.Cell death & disease · 2025Article
- Polycomb repressive complex 2 (PRC2) pathway's role in cancer cell plasticity and drug resistance.Functional & integrative genomics · 2025Review
- Impact of visceral adipose tissue on longevity and metabolic health: a comparative study of gene expression in perirenal and epididymal fat of Ames dwarf mice.GeroScience · 2024Article
- Transgenic Overexpression of HDAC9 Promotes Adipocyte Hypertrophy, Insulin Resistance and Hepatic Steatosis in Aging Mice.Biomolecules · 2024Article
- Histone methylation: at the crossroad between circadian rhythms in transcription and metabolism.Frontiers in genetics · 2024Review
- Identification and Validation of Hub Genes and Construction of miRNA-Gene and Transcription Factor-Gene Networks in Adipogenesis of Mesenchymal Stem Cells.Stem cells international · 2024Article
- Identification of a polycomb group-related gene signature for predicting prognosis and immunotherapy efficacy in lung adenocarcinoma.Journal of thoracic disease · 2023Article
- Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies.Signal transduction and targeted therapy · 2023Review
- Multiomics characteristics and immunotherapeutic potential of EZH2 in pan-cancer.Bioscience reports · 2023Article
Corrections and comments
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Authors and funding
17 authors at 2 institutions in 1 country.
Nicole K H YiewDepartment of Pharmacology and Toxicology, Medical College of Georgia at Augusta University, Augusta, Georgia 30912; Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia 30912.
Charlotte GreenwayVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia 30912.
Abdalrahman ZarzourVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia 30912; Department of Medicine (Division of Cardiology), Medical College of Georgia at Augusta University, Augusta, Georgia 30912.
Samah AhmadiehVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia 30912; Department of Medicine (Division of Cardiology), Medical College of Georgia at Augusta University, Augusta, Georgia 30912.
Brandee GooVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia 30912; Department of Medicine (Division of Cardiology), Medical College of Georgia at Augusta University, Augusta, Georgia 30912.
David KimVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia 30912.
Tyler W BensonVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia 30912.
Mourad OgbiVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia 30912.
Yao Liang TangVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia 30912; Department of Medicine (Division of Cardiology), Medical College of Georgia at Augusta University, Augusta, Georgia 30912.
Weiqin ChenDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia 30912.
David SteppVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia 30912; Department of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia 30912.
Vijay PatelDepartment of Cardiothoracic and Vascular Surgery, Medical College of Georgia at Augusta University, Augusta, Georgia 30912.
Renee HiltonDepartment of Minimally Invasive and Digestive Diseases Surgery, Medical College of Georgia at Augusta University, Augusta, Georgia 30912.
Xin-Yun LuDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia 30912.
David Y HuiDepartment of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267.
Ha Won KimVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia 30912; Department of Medicine (Division of Cardiology), Medical College of Georgia at Augusta University, Augusta, Georgia 30912.
Neal L WeintraubVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia 30912; Department of Medicine (Division of Cardiology), Medical College of Georgia at Augusta University, Augusta, Georgia 30912. Electronic address: nweintraub@augusta.edu.
Augusta University · USUniversity of Cincinnati · US
Funding
Circadian origins of vascular disease in obesityR01HL147159 · NHLBI · AUGUSTA UNIVERSITY · PI FULTON, DAVID J, STEPP, DAVID W · 2019 to 2022
$2.7MInnovative Approaches to Treat Duchenne Muscular Dystrophy Using iPSC-Derived Muscle ProgenitorsR01AR070029 · NIAMS · AUGUSTA UNIVERSITY · PI ASHRAF, MUHAMMAD, TANG, YAO LIANG · 2016 to 2021
$2.6MNotch1/miR-322 Axis in Stem Cell Mediated Vascular RepairR01HL134354 · NHLBI · AUGUSTA UNIVERSITY · PI ASHRAF, MUHAMMAD, TANG, YAO LIANG · 2016 to 2020
$2.5MMechanisms of myeloperoxidase and Nox4 interactions in abdominal aortic aneurysmR01HL142097 · NHLBI · AUGUSTA UNIVERSITY · PI WEINTRAUB, NEAL L · 2018 to 2021
$2.1MEpigenetic regulation of HDAC9 in obesity and atherosclerosisR01HL126949 · NHLBI · AUGUSTA UNIVERSITY · PI WEINTRAUB, NEAL L · 2016 to 2019
$1.8MNHLBI NIH HHS R01 HL126949NHLBI NIH HHS R01 HL134354NHLBI NIH HHS R01 HL142097NHLBI NIH HHS R01 HL147159NIAMS NIH HHS R01 AR070029
Abstract
Enhancer of zeste homolog 2 (EZH2), an epigenetic regulator that plays a key role in cell differentiation and oncogenesis, was reported to promote adipogenic differentiation
Indexed as
Cell DifferentiationLipogenesisLipolysisAdipocytesAnimalsApolipoproteins EEnhancer of Zeste Homolog 2 ProteinHumansLipoproteins, VLDLMiceUp-RegulationApolipoproteins EEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humanEzh2 protein, mouseLipoproteins, VLDLadipocyteapolipoprotein E (ApoE)EZH2lipidlipoproteinobesity
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.