Evidence map›Paper›PMID 30971419›Full record

Trial reportGut2019

Assessing telephone-delivered cognitive-behavioural therapy (CBT) and web-delivered CBT versus treatment as usual in irritable bowel syndrome (ACTIB): a multicentre randomised trial.

Hazel Anne Everitt, Sabine Landau, Gilly O'Reilly, Alice Sibelli, Stephanie Hughes, Sula Windgassen, Rachel Holland, Paul Little, Paul McCrone, Felicity Bishop and 6 more

Open access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Gut, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 5 pooled it
21.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 5 syntheses or guidelines pooled it, 196 citations in OpenAlex.

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  12. Predictors of initial engagement with an asynchronous cognitive behavioral stress management website among older women with nonmetastatic breast cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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  18. Irritable bowel syndrome.Nature reviews. Disease primers · 2026
    Review
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Hazel Anne EverittPrimary Care and Population Sciences, University of Southampton, Southampton, UK.ORCID 0000-0001-7362-8403
Sabine LandauDepartment of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK.
Gilly O'ReillyPrimary Care and Population Sciences, University of Southampton, Southampton, UK.
Alice SibelliDepartment of Psychology, Institue of Psychiatry, Psychology and Neuroscience, King's College, London, UK.
Stephanie HughesPrimary Care and Population Sciences, University of Southampton, Southampton, UK.
Sula WindgassenDepartment of Psychology, Institue of Psychiatry, Psychology and Neuroscience, King's College, London, UK.
Rachel HollandDepartment of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK.
Paul LittlePrimary Care and Population Sciences, University of Southampton, Southampton, UK.
Paul McCroneDepartment of Health Services and Population Research, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK.
Felicity BishopDepartment of Psychology, University of Southampton, Southampton, UK.
Kimberley GoldsmithDepartment of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK.
Nicholas ColemanDepartment of Gastroenterology, University Hospital Southampton, Southampton, UK.
Robert LoganDepartment of Gastroenterology, King's College Hospital, London, UK.
Trudie Chalder *Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK.
Rona Moss-Morris *Department of Psychology, Institue of Psychiatry, Psychology and Neuroscience, King's College, London, UK.
ACTIB trial group
King's College London · GBUniversity of Southampton · GBKing's College Hospital · GBUniversity Hospital Southampton NHS Foundation Trust · GB

Funding

Department of Health 11/69/02
6 · The paper itself

Abstract

objectiveTo evaluate the clinical effectiveness of two modes of cognitive-behavioural therapy (CBT) for IBS compared with treatment as usual (TAU) in refractory IBS.

designA three-arm randomised controlled trial assessing telephone-delivered CBT (TCBT), web-based CBT (WCBT) with minimal therapist support, and TAU. Blinding participants and therapists was not possible. Chief investigator, assessors and statisticians were blinded. Participants were adults with refractory IBS (clinically significant symptoms for ≥12 months despite first-line therapies), recruited by letter and opportunistically from 74 general practices and three gastroenterology centres in London and South of England between May 2014 to March 2016. Co-primary outcomes were IBS Symptom Severity Score (IBS-SSS) and Work and Social Adjustment Scale (WSAS) at 12 months.

results558/1452 (38.4%) patients screened for eligibility were randomised: 76% female: 91% white: mean age 43 years. (391/558) 70.1% completed 12 months of follow-up. Primary outcomes: Compared with TAU (IBS-SSS 205.6 at 12 months), IBS-SSS was 61.6 (95% CI 33.8 to 89.5) points lower (p<0.001) in TCBT and 35.2 (95% CI 12.6 to 57.8) points lower (p=0.002) in WCBT at 12 months. Compared with TAU (WSAS score 10.8 at 12 months) WSAS was 3.5 (95% CI 1.9 to 5.1) points lower (p<0.001) in TCBT and 3.0 (95% CI 1.3 to 4.6) points lower (p=0.001) in WCBT. All secondary outcomes showed significantly greater improvement (p≤0.002) in CBT arms compared with TAU. There were no serious adverse reactions to treatment.

conclusionBoth CBT interventions were superior to TAU up to 12 months of follow-up. TRIAL REGISTRATION NUMBER: ISRCTN44427879.

Indexed as

InternetTelephoneAdultCognitive Behavioral TherapyFemaleFollow-Up StudiesHumansIrritable Bowel SyndromeMaleMiddle AgedPatient ComplianceRemote ConsultationSeverity of Illness IndexTreatment Outcomecognitive-behavioural therapyirritable bowel syndromerandomised controlled trial

Identifiers

PMID30971419
PMCPMC6709776
OpenAlexW2938697113

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.