ArticleMicrobial cell factories2019
Enhanced production of antifungal lipopeptide iturin A by Bacillus amyloliquefaciens LL3 through metabolic engineering and culture conditions optimization.
Article in Microbial cell factories, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 126 citations in OpenAlex.
- Synergistic engineering of monoterpenoid synthase and metabolic pathways to enhance α-terpineol production inSynthetic and systems biotechnology · 2026Article
- Optimization, characterization, and mechanistic evaluation of iturin and surfactin like, broad spectrum antimicrobial lipopeptides from Bacillus subtilis RKEA1 isolated from Acanthus ilicifolius.World journal of microbiology & biotechnology · 2026Article
- Integrative phylogenomic and pangenome landscape of Bacillus: insights from 10,000 genomes into taxonomy, functional potential, and biotechnological applications.World journal of microbiology & biotechnology · 2026Article
- Genome-Guided Identification and Characterisation of Broad-Spectrum Antimicrobial Compounds of Bacillus velezensis Strain PD9 Isolated from Stingless Bee Propolis.Probiotics and antimicrobial proteins · 2025Article
- Biosurfactants as novel antibiofilm agents: mechanisms, biomedical applications, and applications in biofilm-associated infections.Archives of microbiology · 2025Review
- Endophytic and Epiphytic Microorganisms as Biocontrol Agents: Mechanisms, Applications, and Metagenomic Approaches in Tomato Cultivation.Molecules (Basel, Switzerland) · 2025Review
- Efficient Stereochemical Analysis of Hydroxy Fatty Acids Using PGME and PAME Derivatization.Analytical chemistry · 2025Article
- Dynamic regulation of iturin production via reconstructing the quorum-sensing system ComQXPA in Bacillus subtilis.World journal of microbiology & biotechnology · 2025Article
- Engineering of acyl ligase domain in non-ribosomal peptide synthetases to change fatty acid moieties of lipopeptides.Communications chemistry · 2025Article
- Sources of Lipopeptides and Their Applications in Food and Human Health: A Review.Foods (Basel, Switzerland) · 2025Review
- Antimicrobial Activity ofInternational journal of molecular sciences · 2025Review
- Whole genome sequence analysis of Bacillus amyloliquefaciens strain S2.5 as a potential probiotic for feed supplement in livestock production.Journal, genetic engineering & biotechnology · 2024Article
- Elucidating the salt-tolerant mechanism of Halomonas cupida J9 and unsterile ectoine production from lignocellulosic biomass.Microbial cell factories · 2024Article
- Tomato domestication rather than subsequent breeding events reduces microbial associations related to phosphorus recovery.Scientific reports · 2024Article
- Lipopeptides from Bacillus: unveiling biotechnological prospects-sources, properties, and diverse applications.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Review
- Enhancement of herbicolin A production by integrated fermentation optimization and strain engineering in Pantoea agglomerans ZJU23.Microbial cell factories · 2023Article
- Bioengineering for the Microbial Degradation of Petroleum Hydrocarbon Contaminants.Bioengineering (Basel, Switzerland) · 2023Review
- Suppression of Fusarium Wilt in Watermelon byJournal of fungi (Basel, Switzerland) · 2023Article
- Construction ofFrontiers in microbiology · 2023Article
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Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIturins, which belong to antibiotic cyclic lipopeptides mainly produced by Bacillus sp., have the potential for application in biomedicine and biocontrol because of their hemolytic and antifungal properties. Bacillus amyloliquefaciens LL3, isolated previously by our lab, possesses a complete iturin A biosynthetic pathway as shown by genomic analysis. Nevertheless, iturin A could not be synthesized by strain LL3, possibly resulting from low transcription level of the itu operon.
resultsIn this work, enhanced transcription of the iturin A biosynthetic genes was implemented by inserting a strong constitutive promoter C2up into upstream of the itu operon, leading to the production of iturin A with a titer of 37.35 mg l
conclusionsTo our knowledge, this is the first report on simultaneous production of four iturin A homologs (C
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.