ArticlePolymers2017
Tuning the Density of Poly(ethylene glycol) Chains to Control Mammalian Cell and Bacterial Attachment.
Article in Polymers, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 29 citations in OpenAlex.
- Concentrated Polymer Brush-Modified Magnetic Particles for a Diagnostic Immunoassay.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Article
- Single-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection.Nature communications · 2021Article
- Direct metabolite detection with an n-type accumulation mode organic electrochemical transistor.Science advances · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surface modification of biomaterials with polymer chains has attracted great attention because of their ability to control biointerfacial interactions such as protein adsorption, cell attachment and bacterial biofilm formation. The aim of this study was to control the immobilisation of biomolecules on silicon wafers using poly(ethylene glycol)(PEG) chains by a "grafting to" technique. In particular, to control the polymer chain graft density in order to capture proteins and preserve their activity in cell culture as well as find the optimal density that would totally prevent bacterial attachment. The PEG graft density was varied by changing the polymer solubility using an increasing salt concentration. The silicon substrates were initially modified with aminopropyl-triethoxysilane (APTES), where the surface density of amine groups was optimised using different concentrations. The results showed under specific conditions, the PEG density was highest with grafting under "cloud point" conditions. The modified surfaces were characterised with X-ray photoelectron spectroscopy (XPS), ellipsometry, atomic force microscopy (AFM) and water contact angle measurements. In addition, all modified surfaces were tested with protein solutions and in cell (mesenchymal stem cells and MG63 osteoblast-like cells) and bacterial (
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Registered trials
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