Evidence map›Paper›PMID 30970903›Full record

ArticlePolymers2017

Thiol-Ene Photo-Click Collagen-PEG Hydrogels: Impact of Water-Soluble Photoinitiators on Cell Viability, Gelation Kinetics and Rheological Properties.

Róisín Holmes, Xue-Bin Yang, Aishling Dunne, Larisa Florea, David Wood, Giuseppe Tronci

Abstract read
In one paragraph

Article in Polymers, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Review
  2. Review
  3. Thiolated Polymers in 3D Bioprinting: Control of Gelation.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
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  15. The Impact of theMaterials (Basel, Switzerland) · 2022
    Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Róisín HolmesBiomaterials and Tissue Engineering Research Group, School of Dentistry, University of Leeds, Wellcome Trust Brenner Building, St James' University Hospital, Leeds LS9 7TF, UK. mnrh@leeds.ac.uk.
Xue-Bin YangBiomaterials and Tissue Engineering Research Group, School of Dentistry, University of Leeds, Wellcome Trust Brenner Building, St James' University Hospital, Leeds LS9 7TF, UK. x.b.yang@leeds.ac.uk.ORCID 0000-0002-0144-2826
Aishling DunneInsight Centre for Data Analytics, National Centre for Sensor Research, School of Chemical Sciences, Dublin City University, Dublin 9, Glasnevin, Ireland. aishling.dunne58@mail.dcu.ie.
Larisa FloreaInsight Centre for Data Analytics, National Centre for Sensor Research, School of Chemical Sciences, Dublin City University, Dublin 9, Glasnevin, Ireland. larisa.florea@dcu.ie.ORCID 0000-0002-4704-2393
David WoodBiomaterials and Tissue Engineering Research Group, School of Dentistry, University of Leeds, Wellcome Trust Brenner Building, St James' University Hospital, Leeds LS9 7TF, UK. d.j.wood@leeds.ac.uk.
Giuseppe TronciBiomaterials and Tissue Engineering Research Group, School of Dentistry, University of Leeds, Wellcome Trust Brenner Building, St James' University Hospital, Leeds LS9 7TF, UK. g.tronci@leeds.ac.uk.ORCID 0000-0002-9426-4220

Funding

Wellcome Trust
6 · The paper itself

Abstract

Thiol-ene photo-click hydrogels were prepared via step-growth polymerisation using thiol-functionalised type-I collagen and 8-arm poly(ethylene glycol) norbornene-terminated (PEG-NB), as a potential injectable regenerative device. Type-I collagen was thiol-functionalised by a ring opening reaction with 2-iminothiolane (2IT), whereby up to 80 Abs.% functionalisation and 90 RPN% triple helical preservation were recorded via 2,4,6-Trinitrobenzenesulfonic acid (TNBS) colorimetric assay and circular dichroism (CD). Type, i.e., either 2-Hydroxy-1-[4-(2-hydroxyethoxy) phenyl]-2-methyl-1-propanone (I2959) or lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP), and concentration of photoinitiator were varied to ensure minimal photoinitiator-induced cytotoxicity and to enable thiol-ene network formation of collagen-PEG mixtures. The viability of G292 cells following 24 h culture in photoinitiator-supplemented media was largely affected by the photoinitiator concentration, with I2959-supplemented media observed to induce higher toxic response (0.1 → 0.5% (

Indexed as

collagenhydrogelsphotoinitiatorsthiol-ene click chemistry

Identifiers

PMID30970903
PMCPMC6431953

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.