Evidence map›Paper›PMID 30970752›Full record

ReviewPolymers2017

Theoretical Methods for Studying DNA Structural Transitions under Applied Mechanical Constraints.

Artem K Efremov, Ricksen S Winardhi, Jie Yan

Abstract readReview
In one paragraph

Review in Polymers, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Artem K EfremovMechanobiology Institute, National University of Singapore, Singapore 117411, Singapore. mbiay@nus.edu.sg.
Ricksen S WinardhiDepartment of Physics, National University of Singapore, Singapore 117551, Singapore. phyrsw@nus.edu.sg.
Jie YanMechanobiology Institute, National University of Singapore, Singapore 117411, Singapore. phyyj@nus.edu.sg.

Funding

National Research FoundationSingapore Ministry of Education MOE2012-T3-1-001Singapore Ministry of Education MOE2013-T2-1-154
6 · The paper itself

Abstract

Recent progress in single-molecule manipulation technologies has made it possible to exert force and torque on individual DNA biopolymers to probe their mechanical stability and interaction with various DNA-binding proteins. It was revealed in these experiments that the DNA structure and formation of nucleoprotein complexes by DNA-architectural proteins can be strongly modulated by an intricate interplay between the entropic elasticity of DNA and its global topology, which is closely related to the mechanical constraints applied to the DNA. Detailed understanding of the physical processes underlying the DNA behavior observed in single-molecule experiments requires the development of a general theoretical framework, which turned out to be a rather challenging task. Here, we review recent advances in theoretical methods that can be used to interpret single-molecule manipulation experiments on DNA.

Indexed as

DNAequilibrium thermodynamicsforce-spectroscopyphase transition

Identifiers

PMID30970752
PMCPMC6432069

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.