Evidence map›Paper›PMID 30970642›Full record

ArticleCancers2019

NMDA Receptor-Mediated Signaling Pathways Enhance Radiation Resistance, Survival and Migration in Glioblastoma Cells-A Potential Target for Adjuvant Radiotherapy.

Adriana Müller-Längle, Henrik Lutz, Stephanie Hehlgans, Franz Rödel, Kerstin Rau, Bodo Laube

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 51 citations in OpenAlex.

  1. Neuro-tumor interactions in peripheral tumors.Cancer metastasis reviews · 2026
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  20. NMDA Receptor and Its Emerging Role in Cancer.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Adriana Müller-LängleNeurophysiology and Neurosensory Systems, Technische Universität Darmstadt, Schnittspahnstrasse 3, 64287 Darmstadt, Germany. adriana1986@gmx.de.
Henrik LutzNeurophysiology and Neurosensory Systems, Technische Universität Darmstadt, Schnittspahnstrasse 3, 64287 Darmstadt, Germany. lutz@bio.tu-darmstadt.de.
Stephanie HehlgansDepartment of Radiotherapy and Oncology, Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. stephanie.hehlgans@kgu.de.
Franz RödelDepartment of Radiotherapy and Oncology, Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. Franz.Roedel@kgu.de.
Kerstin RauNeurophysiology and Neurosensory Systems, Technische Universität Darmstadt, Schnittspahnstrasse 3, 64287 Darmstadt, Germany. kiki.rau@googlemail.com.
Bodo LaubeNeurophysiology and Neurosensory Systems, Technische Universität Darmstadt, Schnittspahnstrasse 3, 64287 Darmstadt, Germany. laube@bio.tu-darmstadt.de.
Technische Universität Darmstadt · DEGoethe University Frankfurt · DE

Funding

Bundesministerium für Bildung und Forschung 02NUK034BDeutsche Forschungsgemeinschaft GRK1657
6 · The paper itself

Abstract

Glioblastoma is one of the most aggressive malignant brain tumors, with a survival time less than 15 months and characterized by a high radioresistance and the property of infiltrating the brain. Recent data indicate that the malignancy of glioblastomas depends on glutamatergic signaling via ionotropic glutamate receptors. In this study we revealed functional expression of Ca

Indexed as

CREB inhibitorDNA repairifenprodilionotropic glutamate receptorsLN229memantineNMDAR subunit GluN2BradiotherapysulfasalazineU-87MG

Identifiers

PMID30970642
PMCPMC6520759
OpenAlexW2939908713

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.