Evidence map›Paper›PMID 30970641›Full record

ArticleBiomolecules2019

Host-Microbiome Synergistic Control on Sphingolipid Metabolism by Mechanotransduction in Model Arthritis.

Xiaoyuan Zhou, Valentina Devescovi, Yuanhua Liu, Jennifer E Dent, Christine Nardini

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 4 countries.

Xiaoyuan ZhouDepartment of Neurology, University of California, San Francisco, CA 94158, USA. xiaoyuan.zhou@ucsf.edu.
Valentina DevescoviCAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Shanghai 200031, China. valentina.devescovi@gmail.com.
Yuanhua LiuCAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Shanghai 200031, China. yhliu@ips.ac.cn.
Jennifer E DentNORSAS Consultancy Ltd., Hoveton, Norwich, Norfolk, NR128QP, UK. jen.dent@gmail.com.
Christine NardiniCAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Shanghai 200031, China. christine.nardini.rsrc@gmail.com.
Institut Pasteur of Shanghai · CNKarolinska Institutet · SEShanghai Institutes for Biological Sciences · CNUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic inflammatory autoimmune disorders are systemic diseases with increasing incidence and still lack a cure. More recently, attention has been placed in understanding gastrointestinal (GI) dysbiosis and, although important progress has been made in this area, it is currently unclear to what extent microbiome manipulation can be used in the treatment of autoimmune disorders. Via the use of appropriate models, rheumatoid arthritis (RA), a well-known exemplar of such pathologies, can be exploited to shed light on the currently overlooked effects of existing therapies on the GI microbiome. In this direction, we here explore the crosstalk between the GI microbiome and the host immunity in model arthritis (collagen induced arthritis, CIA). By exploiting

Indexed as

Gastrointestinal MicrobiomeHost-Pathogen InteractionsAnimalsAntirheumatic AgentsArthritis, ExperimentalFemaleKiller Cells, NaturalMethotrexatePrevotellaRatsRats, WistarSphingolipidsStress, MechanicalAntirheumatic AgentsMethotrexateSphingolipidshost-microbiome interactioniNKTPrevotella sp.rheumatoid arthritissphingolipids metabolism

Identifiers

PMID30970641
PMCPMC6523851
OpenAlexW2938841016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.