ArticleViruses2019
Annexin II as a Dengue Virus Serotype 2 Interacting Protein Mediating Virus Interaction on Vero Cells.
Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Transcriptomic response of mosquitoes to Japanese encephalitis virus and identification of its potential entry factors.Npj viruses · 2025Article
- Effects of the fatty acid synthase inhibitors triclosan and lapatinib on dengue virus and Zika virus infection.Scientific reports · 2025Article
- Encephalomyocarditis Virus 2A Protein Inhibited Apoptosis by Interaction with Annexin A2 through JNK/c-Jun Pathway.Viruses · 2022Article
- Pathogenesis and virulence of flavivirus infections.Virulence · 2021Review
- Rapid, Cheap, and Effective COVID-19 Diagnostics for Africa.Diagnostics (Basel, Switzerland) · 2021Review
- Molecular Insights on the Possible Role of Annexin A2 in COVID-19 Pathogenesis and Post-Infection Complications.International journal of molecular sciences · 2021Review
- Proteomes, kinases and signalling pathways in virus-induced filopodia, as potential antiviral therapeutics targets.Reviews in medical virology · 2021Review
- The key amino acids of E protein involved in early flavivirus infection: viral entry.Virology journal · 2021Review
- Deciphering flavivirus-host interactions using quantitative proteomics.Current opinion in immunology · 2020Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent evidence has demonstrated that dengue virus requires active filopodia formation for a successful infection. However, the cellular factor involved in the interaction has not been fully elucidated. We used a combination of virus overlay protein binding assay and LC-MS/MS, and identified annexin II as a dengue virus serotype 2 (DENV2) interacting protein on Vero cells, upon filopodia induction. Flow cytometry analysis showed annexin II on the Vero cells surface increased when DENV2 was added. The amount of annexin II in the plasma membrane fraction was reduced as the infection progressed. Antibody-mediated inhibition of infection and siRNA-mediated knockdown of annexin II expression significantly reduced DENV2 infection and production levels. Collectively, we demonstrated that annexin II is one of the host factor involved in DENV2 binding on Vero cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.