ArticleFetal diagnosis and therapy2019
Spinal Angulation: A Limitation of the Fetal Lamb Model of Myelomeningocele.
Article in Fetal diagnosis and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Early investigations into improving bowel and bladder function in fetal ovine myelomeningocele repair.Journal of pediatric surgery · 2022Article
- Efficacy of clinical-grade human placental mesenchymal stromal cells in fetal ovine myelomeningocele repair.Journal of pediatric surgery · 2022Article
- Prenatal Neural Tube Anomalies: A Decade of Intrauterine Stem Cell Transplantation Using Advanced Tissue Engineering Methods.Stem cell reviews and reports · 2022Review
- Long-term safety evaluation of placental mesenchymal stromal cells for in utero repair of myelomeningocele in a novel ovine model.Journal of pediatric surgery · 2022Article
- Placental Mesenchymal Stromal Cells: Preclinical Safety Evaluation for Fetal Myelomeningocele Repair.The Journal of surgical research · 2021Article
- Modern fetal surgery-a historical review of the happenings that shaped modern fetal surgery and its practices.Translational pediatrics · 2021Review
- Preliminary Evaluation of a Novel Fetal Guinea Pig Myelomeningocele Model.BioMed research international · 2021Article
- A Novel Model of Fetal Spinal Cord Exposure Allowing for Long-Term Postnatal Survival.Fetal diagnosis and therapy · 2021Article
- In utero treatment of myelomeningocele with placental mesenchymal stromal cells - Selection of an optimal cell line in preparation for clinical trials.Journal of pediatric surgery · 2020Article
- Surviving Lambs with Myelomeningocele Repaired in utero with Placental Mesenchymal Stromal Cells for 6 Months: A Pilot Study.Fetal diagnosis and therapy · 2020Article
- Hydrogel and neural progenitor cell delivery supports organotypic fetal spinal cord development in anJournal of tissue engineeringArticle
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Authors and funding
10 authors.
Funding
Abstract
introductionThe surgically induced fetal lamb model is the most commonly used large animal model of myelomeningocele (MMC) but is subject to variation due to surgical technique during defect creation. MATERIAL AND
methodsThirty-one fetal lambs underwent creation of the MMC defect, followed by defect repair with either an extracellular matrix (ECM) patch (n = 10) or ECM seeded with placental mesenchymal stromal cells (n = 21). Postnatal hindlimb function was assessed using the Sheep Locomotor Rating (SLR) scale. Postmortem magnetic resonance imaging of the lumbar spine was used to measure the level and degree of spinal angulation, as well as cross-sectional area of remaining vertebral bone.
resultsMedian level of angulation was between the 2nd and 3rd lumbar vertebrae, with a median angle of 24.3 degrees (interquartile range 16.2-35.3). There was a negative correlation between angulation degree and SLR (r = -0.44, p = 0.013). Degree of angulation also negatively correlated with the normalized cross-sectional area of remaining vertebral bone (r = -0.75, p < 0.0001). DISCUSSION: Surgical creation of fetal MMC leads to varying severity of spinal angulation in the ovine model, which affects postnatal functional outcomes. Postnatal assessment of spinal angulation aids in standardization of the surgical model of fetal MMC repair.
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