Evidence map›Paper›PMID 30970141›Full record

ArticleArquivos brasileiros de cardiologia2019

Sympatho-Vagal Imbalance is Associated with Sarcopenia in Male Patients with Heart Failure.

Guilherme Wesley Peixoto da Fonseca, Marcelo Rodrigues Dos Santos, Francis Ribeiro de Souza, Marcel Jose A da Costa, Stephan von Haehling, Liliam Takayama, Rosa Maria R Pereira, Carlos Eduardo Negrão, Stefan D Anker, Maria Janieire de Nazaré Nunes Alves

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PubMed Full text at PMC Publisher
In one paragraph

Article in Arquivos brasileiros de cardiologia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 5 pooled it
4.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 5 syntheses or guidelines pooled it, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Guilherme Wesley Peixoto da FonsecaInstituto do Coração (InCor), São Paulo, SP - Brazil.ORCID 0000-0001-6477-8741
Marcelo Rodrigues Dos SantosInstituto do Coração (InCor), São Paulo, SP - Brazil.ORCID 0000-0003-2926-1311
Francis Ribeiro de SouzaInstituto do Coração (InCor), São Paulo, SP - Brazil.ORCID 0000-0001-8709-8706
Marcel Jose A da CostaInstituto do Coração (InCor), São Paulo, SP - Brazil.
Stephan von HaehlingDepartment of Cardiology and Pneumology - University of Göttingen Medical Centre, Göttingen - Germany.ORCID 0000-0002-9818-042X
Liliam TakayamaDivisão de Reumatologia - Laboratório de Metabolismo Ósseo da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP - Brazil.ORCID 0000-0001-5845-4230
Rosa Maria R PereiraDivisão de Reumatologia - Laboratório de Metabolismo Ósseo da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP - Brazil.ORCID 0000-0002-3723-5028
Carlos Eduardo NegrãoInstituto do Coração (InCor), São Paulo, SP - Brazil.ORCID 0000-0003-4652-1226
Stefan D AnkerDepartment of Cardiology and Pneumology - University of Göttingen Medical Centre, Göttingen - Germany.ORCID 0000-0003-3331-7314
Maria Janieire de Nazaré Nunes AlvesInstituto do Coração (InCor), São Paulo, SP - Brazil.ORCID 0000-0003-3207-623X
Hospital do Coração · BRHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRUniversity of Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundResting sympathetic hyperactivity and impaired parasympathetic reactivation after exercise have been described in patients with heart failure (HF). However, the association of these autonomic changes in patients with HF and sarcopenia is unknown.

objectiveThe aim of this study was to evaluate the impact of autonomic modulation on sarcopenia in male patients with HF.

methodsWe enrolled 116 male patients with HF and left ventricular ejection fraction < 40%. All patients underwent a maximal cardiopulmonary exercise testing. Maximal heart rate was recorded and delta heart rate recovery (∆HRR) was assessed at 1st and 2nd minutes after exercise. Muscle sympathetic nerve activity (MSNA) was recorded by microneurography. Dual-energy X-ray absorptiometry was used to measure body composition and sarcopenia was defined by the sum of appendicular lean muscle mass (ALM) divided by height in meters squared and handgrip strength.

resultsSarcopenia was identified in 33 patients (28%). Patients with sarcopenia had higher MSNA than those without (47 [41-52] vs. 40 [34-48] bursts/min, p = 0.028). Sarcopenic patients showed lower ∆HRR at 1st (15 [10-21] vs. 22 [16-30] beats/min, p < 0.001) and 2nd min (25 [19-39] vs. 35 [24-48] beats/min, p = 0.017) than non-sarcopenic. There was a positive correlation between ALM and ∆HRR at 1st (r = 0.26, p = 0.008) and 2nd min (r = 0.25, p = 0.012). We observed a negative correlation between ALM and MSNA (r = -0.29, p = 0.003).

conclusionSympatho-vagal imbalance seems to be associated with sarcopenia in male patients with HF. These results highlight the importance of a therapeutic approach in patients with muscle wasting and increased peripheral sympathetic outflow.

Indexed as

AdultAgedAutonomic Nervous SystemExercise TestHand StrengthHeart FailureHeart RateHumansMaleMiddle AgedMuscle StrengthOxygen ConsumptionSarcopeniaSympathetic Nervous SystemYoung Adult

Identifiers

PMID30970141
PMCPMC6636362
OpenAlexW2920995270

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.