ArticleJournal of applied oral science : revista FOB2019
Diversity of clinical, radiographic and genealogical findings in 41 families with amelogenesis imperfecta.
Article in Journal of applied oral science : revista FOB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- An investigation of dental anomalies in individuals with amelogenesis imperfecta.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Full-Mouth Reconstruction in Amelogenesis Imperfecta: A Case Report.The American journal of case reports · 2026Article
- Article
- Full-mouth rehabilitation with lithium disilicate ceramic crowns in hypoplastic amelogenesis imperfecta: a case report and review of literature.BMC oral health · 2024Review
- Interdisciplinary full mouth rehabilitation of a patient with amelogenesis imperfecta from childhood to young adult-hood: A 12-year case report.Clinical case reports · 2024Article
- Prosthodontic rehabilitation of two siblings with hypoplastic (type 1) amelogenesis imperfecta: A case report.Heliyon · 2024Article
- Article
- Contemporary Understanding of the Etiology and Management of Molar Incisor Hypomineralization: A Literature Review.Dentistry journal · 2023Review
- Integration of multimodal data in the developing tooth reveals candidate regulatory loci driving human odontogenic phenotypes.Frontiers in dental medicine · 2022Article
- Restoration of the dentition in a patient with a history of bruxism and amelogenesis imperfecta: A clinical report.Clinical case reports · 2021Article
- DMF Index among Amelogenesis Imperfecta Patients: Systematic Review of the Literature.International journal of dentistry · 2021Review
- Alteration of Exon Definition Causes Amelogenesis Imperfecta.Journal of dental research · 2020Article
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amelogenesis imperfecta (AI) is a group of enamel development disorders that alter the structure and chemical composition of the tissue. There is great variability in the clinical presentation; according to Witkop, AI can be categorized into 14 subtypes, which makes its diagnosis extremely complex.
objectiveThis study aimed to describe and determine the frequency of clinical and radiographic features and inheritance patterns found in 41 Chilean families diagnosed with diverse types of AI. MATERIAL AND
methodsWe analyzed the clinical records, photographs, pedigrees and radiographs of 121 individuals recruited between 2003 and 2016. All of the information was included in a database that was analyzed using the application Stata 14.
resultsThe 72 affected individuals had average age of 16 years, and no sex association with the presence of AI was found. The most frequent clinical subtypes were as follows: 43% hypomature, 25% hypoplastic, 21% hypomature/hypoplastic, 7% hypocalcified and 4% hypocalcified/hypoplastic. The number of severely affected teeth was 22, which occurred in the patients with hypocalcified and hypocalcified/hypoplasic AI who presented the highest number of damaged teeth. Caries and periodontal disease were found in 47 and 32% of the patients, respectively. Malocclusions were observed in 43% of the individuals with AI, with open bite being the most frequent. Radiographically, the thickness of the enamel decreased in 51% of the patients, and 80% showed decreased radiopacity of the enamel compared to that of dentin. Autosomal dominant inheritance pattern was found in 37% of the families with hypoplastic AI, and autosomal recessive pattern was present in 56% of the other clinical subtypes, but more frequently in those affected with hypomature and hypocalcified AI.
conclusionOf the five clinical subtypes, autosomal recessive hypomature, autosomal dominant hypoplastic and autosomal recessive hypomature/hypoplastic AI were the most prevalent subtypes in this group.
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