SynthesisPLoS neglected tropical diseases2019
Relationship between toxoplasmosis and obsessive compulsive disorder: A systematic review and meta-analysis.
Synthesis in PLoS neglected tropical diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 6 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Systematic Review on the Relationship between Toxoplasmosis and Mental Disorders.Actas espanolas de psiquiatria · 2024Pooled it
- Toxoplasma gondii infection and testosterone alteration: A systematic review and meta-analyses.PloS one · 2024Pooled it
- Toxoplasma infection and Rhesus blood group system: A systematic review and meta-analysis.PloS one · 2023Pooled it
- Potential risk factors associated with seropositivity for Toxoplasma gondii among pregnant women and HIV infected individuals in Ethiopia: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2020Pooled it
- Pooled it
- Is there any association between Toxoplasma gondii infection and depression? A systematic review and meta-analysis.PloS one · 2019Pooled it
- A review onParasite epidemiology and control · 2026Review
- Article
- Beyond Latency: ChronicBiomedicines · 2025Review
- Association between latent toxoplasmosis and bipolar disorder: a case-control seroprevalence study.BMC infectious diseases · 2025Article
- Diseases Caused by and Behaviors Associated withPathogens (Basel, Switzerland) · 2024Review
- Effective factors in the pathogenesis ofHeliyon · 2024Review
- Positive Toxoplasma IgG Serology Is Associated with Increased Overall Mortality - A Propensity Score-Matched Analysis.The American journal of tropical medicine and hygiene · 2024Article
- Silent Infections are not So Silent: The Emerging Role of Combined Infections, Inflammation, and Vitamin Levels in OCD.Clinical neuropsychiatry · 2024Article
- Survey on the association between Toxoplasma gondii infection and violent behavior in inmates.PloS one · 2023Article
- Back to the Future: The Role of Infections in Psychopathology. Focus on OCD.Clinical neuropsychiatry · 2022Article
- The Association ofInternational journal of environmental research and public health · 2022Article
- Impact of Plant-Based Foods and Nutraceuticals onFrontiers in nutrition · 2022Review
- Toxoplasmosis: Targeting neurotransmitter systems in psychiatric disorders.Metabolic brain disease · 2022Review
- Comprehensive Overview ofPathogens (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA few studies investigated the relationship between toxoplasmosis and mental disorders, such as obsessive compulsive disorder (OCD). However, the specific nature of the association between Toxoplasma gondii (T. gondii) infection and OCD is not yet clear. The aim of this study was to collect information on the relationship between OCD and toxoplasmosis and assess whether patients with toxoplasmosis are prone to OCD.
methodsFor the purpose of this study, 6 major electronic databases and the Internet search engine Google Scholar were searched for the published articles up to July 30th, 2018 with no restriction of language. The inverse variance method and the random effect model were used to combine the data. The values of odds ratio (OR) were estimated at 95% confidence interval (CI).
resultsA total of 9 case-control and 3 cross-sectional studies were included in our systematic review. However, 11 of these 12 articles were entered into the meta-analysis containing 9873 participants, out of whom 389 were with OCD (25.96% positive for toxoplasmosis) and 9484 were without OCD (17.12% positive for toxoplasmosis). The estimation of the random effect model indicated a significant common OR of 1.96 [95% CI: 1.32-2.90].
conclusionThis systematic review and meta-analysis revealed that toxoplasmosis could be as an associated factor for OCD (OR = 1.96). However, further prospective investigations are highly recommended to illuminate the underlying pathophysiological mechanisms of T. gondii infection in OCD and to better investigate the relationship between OCD and T. gondii infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.